Enlarge / Packaging for Wegovy, manufactured by Novo Nordisk, is seen in this illustration photo. (credit: Getty | Jakub Porzycki)

With the debut of remarkably effective weight-loss drugs, America's high obesity rate and its uniquely astronomical prescription drug pricing appear to be set on a catastrophic collision course—one that threatens to "bankrupt our entire health care system," according to a new Senate report that modeled the economic impact of the drugs in different uptake scenarios.

If just half of the adults in the US with obesity start taking a new weight-loss drug, such as Wegovy, the collective cost would total an estimated $411 billion per year, the analysis found. That's more than the $406 billion Americans spent in 2022 on all prescription drugs combined.

While the bulk of the spending on weight-loss drugs will occur in the commercial market—which could easily lead to spikes in health insurance premiums—taxpayer-funded Medicare and Medicaid programs will also see an extraordinary financial burden. In the scenario that half of adults with obesity go on the drug, the cost to those federal programs would total $166 billion per year, rivaling the programs' total 2022 drug costs of $175 billion.

Enlarge (credit: Sarah Dussault/MediaNews Group/The Mercury News via Getty Images)

An autopsy report of a Massachusetts teen who tragically died hours after eating an ultra-spicy tortilla chip suggested that his death was due to the high dose of spice in the chip and a congenital heart defect, according to reporting by the Associated Press.

Harris Wolobah, a previously healthy 14-year-old from Worcester, died September 1, 2023 hours after eating the chip—a 2023 Paqui One Chip Challenge chip—which were sold individually, wrapped in tin foil, and seasoned with two of hottest peppers in the world, the Naga Viper pepper and the Carolina Reaper pepper. Paqui sold the chip with a challenge in which eaters were dared to consume the chip, wait as long as possible before eating or drinking anything, and post the aftermath on social media, where the challenge went viral.

Harris' mother, Lois Wolobah, immediately suspected the chip was involved in his untimely death. At the time, she reportedly said she picked him up from school after getting a call from the nurse. He was clutching his stomach and, about two hours later, lost consciousness and was rushed to the hospital, where he died. She reported that he had no known medical conditions at the time.

Enlarge (credit: Getty | Spencer Platt)

The North Carolina State Senate on Wednesday voted 30–15, along party lines, in favor of a Republican bill that would make it illegal for people in the state to wear a mask in public for health reasons. The bill is now moving to the House, where it could potentially see changes.

The proposed ban on health-based masking is part of a larger bill otherwise aimed at increasing penalties for people wearing masks to conceal their identity while committing a crime or impeding traffic. The bill was largely spurred by recent protests on university and college campuses across the country, including North Carolina-based schools, against the war in Gaza. In recent months, there have been demonstrations in Raleigh and Durham that have blocked roadways, as well as clashes on the nearby campus of the University of North Carolina at Chapel Hill. Some demonstrators were seen wearing masks in those events.

But the bill, House Bill 237, goes a step further by making it illegal to wear a mask in public for health and safety reasons, either to protect the wearer, those around them, or both. Specifically, the bill repeals a 2020 legal exemption enacted amid the COVID-19 pandemic, which allowed for public health-based masking for the first time in decades.

Enlarge / A child cools off under a water sprinkler. (credit: Getty | JASON SOUTH)

In 1989, a city in Utah upgraded its drinking water system, putting in a whole new system and repurposing the old one to supply cheap untreated water for irrigating lawns and putting out fires. That meant that the treated water suitable for drinking flowed from new spigots, while untreated water gushed from the old ones. Decades went by with no apparent confusion; residents seemed clear on the two different water sources. But, according to an investigation report published recently by state and county health officials, that local knowledge got diluted as new residents moved into the area. And last summer, the confusion over the conduits led to an outbreak of life-threatening illnesses among children.

In July and August of 2023, state and local health officials identified 13 children infected with Shiga toxin-producing Escherichia coli (STEC) O157:H7. The children ranged in age from 1 to 15, with a median age of 4. Children are generally at high risk of severe infections with this pathogen, along with older people and those with compromised immune systems. Of the 13 infected children, seven were hospitalized and two developed hemolytic uremic syndrome, a life-threatening complication that can lead to kidney failure.

Preliminary genetic analyses of STEC O157:H7 from two of the children suggested that the children's infections were linked to a common source. So, health officials quickly developed a questionnaire to narrow down the potential source. It soon became clear that the irrigation water—aka untreated, pressurized, municipal irrigation water (UPMIW)—was a commonality among the children. Twelve of 13 infected children reported exposure to it in some form: Two said they drank it; five played with UPMIW hoses; three used the water for inflatable water toys; two used it for a water table; and one ran through sprinklers. None reported eating fruits or vegetables from home (noncommercial) gardens irrigated with the UPMIW.

Enlarge / Wegovy is an injectable prescription weight-loss medicine that has helped people with obesity. (credit: Getty | Michael Siluk)

A large, long-term trial of the weight-loss medication Wegovy (semaglutide) found that people tended to lose weight over the first 65 weeks on the drug—about one year and three months—but then hit a plateau or "set point." But that early weight loss was generally maintained for up to four years while people continued taking the weekly injections.

The findings, published Monday in Nature Medicine, come from a fresh analysis of data from the SELECT trial, which was designed to look at the drug's effects on cardiovascular health. The trial—a multicenter, double-blind, randomized, placebo-controlled trial—specifically enrolled people with existing cardiovascular disease who also were overweight or obese but did not have diabetes. In all, the trial included 17,604 people from 41 countries. Seventy-two percent of them were male, 84 percent were white, and the average age was about 62 years old.

Last year, researchers published the trial's primary results, which showed that semaglutide reduced participants' risk of heart attack, stroke, and cardiovascular-related deaths by 20 percent over the span of a little over three years.

Enlarge / A glass of fresh raw milk in the hand of a farmer. (credit: Getty | Pierre Crom)

To drink raw milk at any time is to flirt with dangerous germs. But, amid an unprecedented outbreak of H5N1 bird flu in US dairy cows, the risks have ratcheted up considerably. Health experts have stepped up warnings against drinking raw milk during the outbreak, the scope of which is still unknown.

Yet, raw milk enthusiasts are undaunted by the heightened risk. The California-based Raw Milk Institute called the warnings "clearly fearmongering." The institute's founder, Mark McAfee, told the Los Angeles Times this weekend that his customers are, in fact, specifically requesting raw milk from H5N1-infected cows. According to McAfee, his customers believe, without evidence, that directly drinking high levels of the avian influenza virus will give them immunity to the deadly pathogen.

Expert Michael Payne told the LA Times that the idea amounts to "playing Russian roulette with your health." Payne, a researcher and dairy outreach coordinator at the Western Institute for Food Safety and Security at UC Davis, added, "Deliberately trying to infect yourself with a known pathogen flies in the face of all medical knowledge and common sense."

Enlarge / Opal Sandy (center), who was born completely deaf because of a rare genetic condition, can now hear unaided for the first time after receiving gene therapy at 11 months old. She is shown with her mother, father, and sister at their home in Eynsham, Oxfordshire, on May 7, 2024. (credit: Getty | Andrew Matthews)

There are few things more heartwarming than videos of children with deafness gaining the ability to hear, showing them happily turning their heads at the sound of their parents' voices and joyfully bobbing to newly discovered music. Thanks to recent advances in gene therapy, more kids are getting those sweet and triumphant moments—with no hearing aids or cochlear implants needed.

At the annual conference of the American Society for Gene & Cell Therapy held in Baltimore this week, researchers showed many of those videos to their audiences of experts. On Wednesday, Larry Lustig, an otolaryngologist at Columbia University, presented clinical trial data of two children with profound deafness—the most severe type of deafness—who are now able to hear at normal levels after receiving an experimental gene therapy. One of the children was 11 months old at the time of the treatment, marking her as the youngest child in the world to date to receive gene therapy for genetic deafness.

On Thursday, Yilai Shu, an otolaryngologist at Fudan University in Shanghai, provided a one-year progress report on six children who were treated in the first in-human trial of gene therapy for genetic deafness. Five of the six had their hearing restored.

Enlarge / Elon Musk, in Paris, France, on Friday, June 16, 2023. Musk predicted his Neuralink Corp. would carry out its first brain implant later that year. The first implantation took place in January 2024. (credit: Getty | Nathan Laine)

The first invasive brain chip that Neuralink embedded into a human brain has malfunctioned, with neuron-surveilling threads appearing to have become dislodged from the participant's brain, the company revealed in a blog post Wednesday.

It's unclear what caused the threads to become "retracted" from the brain, how many have retracted, or if the displaced threads pose a safety risk. Neuralink, the brain-computer interface startup run by controversial billionaire Elon Musk, did not immediately respond to a request for comment from Ars. The company said in its blog post that the problem began in late February, but it has since been able to compensate for the lost data to some extent by modifying its algorithm.

Neuralink touts that its invasive implant includes 64 flexible threads carrying a total of 1,024 electrodes that can detect neuronal activity. Those flexible threads—described as thinner than a human hair—are inserted individually into the brain by the company's proprietary surgical robot. The goal is for the threads to be placed near neurons of interest so that signals detected by the electrodes can be recorded and decoded into intended actions, such as moving a cursor on a computer screen.

Enlarge / Dispensers for Charged Lemondade, a caffeinated lemonade drink, at Panera Bread, Walnut Creek, California, March 27, 2023. (credit: Getty | Smith Collection/Gado)

Panera Bread will stop selling its highly caffeinated "Charged" drinks, which have been the subject of at least three lawsuits and linked to at least two deaths.

It is unclear when exactly the company will pull the plug on the potent potables, but in a statement to Ars Tuesday, Panera said it was undergoing a "menu transformation" that includes an "enhanced beverage portfolio." The company plans to roll out various new drinks, including a lemonade and tea, but a spokesperson confirmed that the new flavors would not contain added caffeine as the "charged" drinks did.

The fast-casual cafe-style chain drew national attention in 2022 for the unexpectedly high caffeine levels in the drinks, which were initially offered as self-serve with free refills.

Enlarge (credit: Getty | Julian Stratenschulte)

The field of dentistry is lagging on adopting evidence-based care and, as such, is rife with overdiagnoses and overtreatments that may align more with the economic pressures of keeping a dental practice afloat than what care patients actually need. At least, that's according to a trio of health and dental researchers from Brazil and the United Kingdom, led by epidemiologist and dentist Paulo Nadanovsky, of the University of the State of Rio de Janeiro.

In a viewpoint published Monday in JAMA Internal Medicine, the researchers point out that many common—nearly unquestioned—practices in dentistry aren't backed up by solid data. That includes the typical recommendation that everyone should get a dental check-up every six months. The researchers note that two large clinical trials failed to find a benefit of six-month check-ups compared with longer intervals that were up to two years.

A 2020 Cochrane review that assessed the two clinical trials concluded that "whether adults see their dentist for a check‐up every six months or at personalized intervals based on their dentist's assessment of their risk of dental disease does not affect tooth decay, gum disease, or quality of life. Longer intervals (up to 24 months) between check‐ups may not negatively affect these outcomes." The Cochrane reviewers reported that they were "confident" of little to no difference between six-month and risk-based check-ups and were "moderately confident" that going up to 24-month checkups would make little to no difference either.

Enlarge / Cleveland doctor Sherri Tenpenny gives false testimony on June 8, 2021, saying COVID-19 vaccines magnetize people. (credit: The Ohio Channel)

An anti-vaccine doctor best known for losing her medical license after falsely claiming that COVID-19 vaccines cause people to become magnetic and "interface" with 5G towers, has had her medical license restored, according to local media reports.

Sherri Tenpenny, an osteopathic doctor in the Cleveland area, beamed into the national spotlight in June 2021 while giving repelling testimony before state lawmakers about COVID-19 vaccine recipients. "I'm sure you've seen the pictures all over the Internet of people who have had these shots and now they're magnetized," Tenpenny said in her viral testimony. "You can put a key on their forehead—it sticks. You can put spoons and forks all over and they can stick because now we think there is a metal piece to that."

Her testimony was in support of a bill that would largely ban vaccine mandates in Ohio. The bill never made it out of committee. But the state's medical board opened an investigation the next month. The board intended to ask Tenpenny a variety of questions, including about her statements "regarding COVID-19 vaccines causing people to become magnetized or creating an interface with 5G towers… and regarding some major metropolitan areas liquefying dead bodies and pouring them into the water supply," according to a board report.

Enlarge / Holstein dairy cows in a freestall barn. (credit: Getty | )

The US Department of Agriculture this week posted an unpublished version of its genetic analysis into the spillover and spread of bird flu into US dairy cattle, offering the most complete look yet at the data state and federal investigators have amassed in the unexpected and worrisome outbreak—and what it might mean.

The preprint analysis provides several significant insights into the outbreak—from when it may have actually started, just how much transmission we're missing, stunning unknowns about the only human infection linked to the outbreak, and how much the virus continues to evolve in cows. The information is critical as flu experts fear the outbreak is heightening the ever-present risk that this wily flu virus will evolve to spread among humans and spark a pandemic.

But, the information hasn't been easy to come by. Since March 25—when the USDA confirmed for the first time that a herd of US dairy cows had contracted the highly pathogenic avian influenza H5N1 virus—the agency has garnered international criticism for not sharing data quickly or completely. On April 21, the agency dumped over 200 genetic sequences into public databases amid pressure from outside experts. However, many of those sequences lack descriptive metadata, which normally contains basic and key bits of information, like when and where the viral sample was taken. Outside experts don't have that crucial information, making independent analyses frustratingly limited. Thus, the new USDA analysis—which presumably includes that data—offers the best yet glimpse of the complete information on the outbreak.

Enlarge / A dog gets examined by veterinary technicians in Texas. (credit: Getty | Michael Paulsen)

Two separately owned dogs in New Jersey tested positive last year for a dreaded, extensively drug resistant bacterial strain spread in the US by contaminated artificial eye drops manufactured in India. Those drops caused a deadly multi-state outbreak in humans over many months last year, with at least 81 people ultimately infected across 18 states. Fourteen people lost their vision, an additional four had eyeballs surgically removed, and four people died.

The preliminary data on the dogs—presented recently at a conference of disease detectives hosted by the Centers for Disease Control and Prevention—highlights that now that the deadly outbreak strain has been introduced around the US, it has the potential to lurk in unexpected places, spread its drug resistance to fellow bacteria, and cause new infections in people and animals who may have never used the drops.

The two dogs in New Jersey were not known to have received the drops linked to the outbreak: EzriCare Artificial Tears and two additional products made by the same manufacturer, which were recalled in February 2023. Such over-the-counter products are sometimes used in animals as well as people. But the dogs' separate owners said they didn't recall using the drops either. They also didn't report any exposures in health care settings or recent international travel that could explain the infections. One of the dogs did, at one point, receive eye drops, but they were not an outbreak-associated brand. The only connection between the two dogs was that they were both treated at the same veterinary hospital, which didn't stock the outbreak-associated eyedrops.