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Predictive blood test hailed as ‘incredibly exciting’ breast cancer breakthrough

New ‘liquid biopsy’ will act as an early warning sign to anticipate risk of tumours returning

A new blood test can predict the risk of breast cancer returning three years before any tumours show up on scans in an “incredibly exciting” breakthrough that could help more women beat the disease for good.

More than 2 million women are diagnosed every year with breast cancer, the most prevalent type of the disease. Although treatment has improved in recent decades, the cancer often returns, and if it does, it is usually at a more advanced stage.

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© Photograph: Malcolm Park sciences/Alamy

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© Photograph: Malcolm Park sciences/Alamy

Boeing’s Starliner test flight scrubbed again after hold in final countdown

NASA commander Butch Wilmore exits the Starliner spacecraft Saturday following the scrubbed launch attempt.

Enlarge / NASA commander Butch Wilmore exits the Starliner spacecraft Saturday following the scrubbed launch attempt.

A computer controlling the Atlas V rocket's countdown triggered an automatic hold less than four minutes prior to liftoff of Boeing's commercial Starliner spacecraft Saturday, keeping the crew test flight on the ground at least a few more days.

NASA astronauts Butch Wilmore and Suni Williams were already aboard the spacecraft when the countdown stopped due to a problem with a ground computer. "Hold. Hold. Hold," a member of Atlas V launch team called out on an audio feed.

With the hold, the mission missed an instantaneous launch opportunity at 12:25 pm EDT (16:25 UTC), and later Saturday, NASA announced teams will forego a launch opportunity Sunday. The next chance to send Starliner into orbit will be 10:52 am EDT (14:52 UTC) Wednesday. The mission has one launch opportunity every one-to-two days, when the International Space Station's orbital track moves back into proper alignment with the Atlas V rocket's launch pad in Florida.

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‘Once in a lifetime’: UK and European space scientists urged to join Nasa mission to Uranus

Astrophysicists call for international cooperation on ambitious probe, amid growing interest in the mysterious planet

European space scientists have been urged to join forces with Nasa to ensure the success of one of the most ambitious space missions planned for launch this century.

Joining a robot spaceflight to the mysterious planet Uranus would offer “the opportunity to participate in a groundbreaking, flagship-class mission”, astrophysicists have said.

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© Photograph: Heritage Images/Getty Images

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© Photograph: Heritage Images/Getty Images

Can psychedelics treat depression? Maybe, and you might not even have to take a trip

The use of the drugs in treating low mood has sparked debate, not least about the necessity of a hallucinogenic experience. But a new discovery may provide an answer

Robitussin has been a staple of American pharmacies since the late 1940s – but since the 1960s, people have swigged bottles of the cough medicine recreationally because, at a high enough dose, its active ingredient, dextromethorphan, can cause hallucinations (so-called “robotripping”). Now, that ingredient, common to many cough medications, has a potential new use – as an antidepressant.

In recent years, studies have found that conventional antidepressants are only marginally more effective than biologically inactive placebos. Meanwhile, big pharmaceutical companies conduct very little research into mental health drugs. So researchers and sufferers have instead placed their hopes in psychedelic drugs usually considered hallucinatory, such as psilocybin or LSD. Yet the evidence of their effectiveness as an antidepressant comes from small trials, one of the largest involving just 233 people – and no national government medicine regulator has formally approved them for this use. Against this backdrop, a legitimate drug company has quietly moved dextromethorphan beyond robotripping into a, legally approved depression treatment – but with an important twist.

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© Photograph: Microgen Images/SCIENCE PHOTO LIBRARY/Getty Images/Science Photo Library RF

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© Photograph: Microgen Images/SCIENCE PHOTO LIBRARY/Getty Images/Science Photo Library RF

Sensor error means New Delhi heatwave record overstated by 3C

Meteorologists found 52.9C reading to be false, though new record does appear to have been set

A record temperature registered this week for the Indian capital of 52.9C (127.22F) was too high by 3C, the Indian government has said.

The Indian Meteorological Department (IMD) had investigated Wednesday’s reading by the weather station at Mungeshpur, a densely packed corner of New Delhi, “and found a 3C sensor error”, the earth sciences minister, Kiren Rijiju, said.

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© Photograph: Manish Swarup/AP

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© Photograph: Manish Swarup/AP

Here’s why a Japanese billionaire just canceled his lunar flight on Starship

Elon Musk speaks as Yusaku Maezawa, founder and president of Start Today Co., looks on at an event at the SpaceX headquarters in Hawthorne, California, in 2018.

Enlarge / Elon Musk speaks as Yusaku Maezawa, founder and president of Start Today Co., looks on at an event at the SpaceX headquarters in Hawthorne, California, in 2018. (credit: Patrick T. Fallon/Bloomberg via Getty Images)

On Friday night the dearMoon project—a plan to launch a Japanese billionaire and 10 other 'crew members' on a circumlunar flight aboard SpaceX's Starship vehicle—was abruptly canceled.

"It is unfortunate to be announcing that 'dearMoon', the first private circumlunar flight project, will be cancelled," the mission's official account on the social media site X said. "We thank everyone who has supported us and apologize to those who have looked forward to this project."

Shortly afterward the financial backer of the project and its 'crew leader,' Yusaku Maezawa, explained this decision on X. When Maezawa agreed to the mission in 2018, he said, the assumption was that the dearMoon mission would launch by the end of 2023.

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Daily Telescope: The most distant galaxy found so far is a total surprise

Behold, the most distant galaxy found to date.

Enlarge / Behold, the most distant galaxy found to date. (credit: NASA, ESA, CSA, STScI et al.)

Welcome to the Daily Telescope. There is a little too much darkness in this world and not enough light, a little too much pseudoscience and not enough science. We'll let other publications offer you a daily horoscope. At Ars Technica, we're going to take a different route, finding inspiration from very real images of a universe that is filled with stars and wonder.

Good morning. It's June 1, and today's photo comes from the James Webb Space Telescope. It's a banger.

This telescope, launched 18 months ago now, had as one of its express goals to deliver insights about the early Universe. The most straightforward way of doing so is to collect the faintest, most distant light that has spent the longest time traveling to reach Earth.

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Nitrogen-using bacteria can cut farms’ greenhouse gas emissions 

A tractor amidst many rows of small plants, with brown hills in the background.

Enlarge (credit: Timothy Hearsum)

Fritz Haber: good guy or bad guy? He won the Nobel Prize in Chemistry in 1918 for his part in developing the Haber-Bosch process, a method for generating ammonia using the nitrogen gas in air. The technique freed agriculture from the constraint of needing to source guano or manure for nitrogen fertilizer and is widely credited for saving millions from starvation. About half of the world’s current food supply relies on fertilizers made using it, and about half of the nitrogen atoms in our bodies can be traced back to it.

But it also allowed farmers to use this newly abundant synthetic nitrogen fertilizer with abandon. This has accentuated agriculture’s role as a significant contributor to global warming because the emissions that result from these fertilizers is a greenhouse gas—one that has a warming potential almost 300 times greater than that of carbon dioxide and remains in the atmosphere for 100 years. Microbes in soil convert nitrogen fertilizer into nitrous oxide, and the more nitrogen fertilizer they have to work with, the more nitrous oxide they make.

Agriculture also leaks plenty of the excess nitrogen into waterways in the form of nitrate, generating algal blooms that create low-oxygen ‘dead zones’ where no marine life can live.

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Using your head: neuroscience is fast becoming football’s gamechanger

By harnessing brain power and speeding up ability to process information, players are being helped to fulfil their potential

Four years ago, Arsène Wenger was asked what he thought would be the next game-changer in football. His answer was neuroscience. “Why? Because we are at the end of the improvement of physical speed,” Wenger said. “In the last 10 years, the power and speed of individual players has improved, but now you have sprinters everywhere. The next step will be to improve the speed of our brains.”

Neuroscience is the study of the human nervous system, particularly the brain, and all the multitudinous connections and interactions that go on within it. It is a branch of science that, in the popular imagination, summons up images of electrodes and scanners and illuminated sections of the cerebellum. In football, it has also become a term to refer to a better understanding of the mental skills and qualities necessary to succeed in the game.

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© Photograph: James Gill/Danehouse/Getty Images

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© Photograph: James Gill/Danehouse/Getty Images

Scientists develop method of making healthier, more sustainable chocolate

Approach replaces sugar with mashed pulp and husk of cocoa pod and uses less land and water

Healthier and more sustainable chocolate could hit store shelves after Swiss scientists and chocolatiers developed a recipe that swaps sugar for waste plant matter.

By mashing up the pulp and husk of a cocoa pod instead of just taking the beans, scientists have made a sweet and fibrous gel that could replace the sugar in chocolate, according to a report published in Nature Food.

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© Photograph: Maurice Savage/Alamy

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© Photograph: Maurice Savage/Alamy

Scientists Find the Largest Known Genome Inside a Small Plant

An anonymous reader quotes a report from the New York Times: Last year, Jaume Pellicer led a team of fellow scientists into a forest on Grande Terre, an island east of Australia. They were in search of a fern called Tmesipteris oblanceolata. Standing just a few inches tall, it was not easy to find on the forest floor. "It doesn't catch the eye," said Dr. Pellicer, who works at the Botanical Institute of Barcelona in Spain. "You would probably step on it and not even realize it." The scientists eventually managed to spot the nondescript fern. When Dr. Pellicer and his colleagues studied it in the lab, they discovered it held an extraordinary secret. Tmesipteris oblanceolata has the largest known genome on Earth. As the researchers described in a study published on Friday, the fern's cells contain more than 50 times as much DNA as ours do. [The analysis revealed the species T. oblanceolata to have a record-breaking genome size of 160.45 Gbp, which is about 7% larger than that of P. japonica (148.89 Gbp). For comparison, the human genome contains about 3.1 Gbp distributed across 23 chromosomes and when stretched out like a ball of yarn, the length of DNA in each cell only measures about 2m.] "Surprisingly, having a larger genome is usually not an advantage," notes Phys.org in a report. "In the case of plants, species possessing large amounts of DNA are restricted to being slow growing perennials, are less efficient at photosynthesis (the process by which plants convert the sun's energy into sugars) and require more nutrients (especially nitrogen and phosphates) to grow and compete successfully with their smaller-genomed neighbors. In turn, such effects may influence the ability of a plant to adapt to climate change and their risk of extinction." "In animals, some of the largest genomes include the marbled lungfish (Protopterus aethiopicus) at 129.90 Gbp and the Neuse River waterdog (Necturus lewisi) at 117.47 Gbp," reports Phys.org. "In stark contrast, six of the largest-known eukaryotic genomes are held by plants, including the European mistletoe (Viscum album) at 100.84 Gbp."

Read more of this story at Slashdot.

Scientists develop cheap and quick spit test for prostate cancer

DNA test, which takes seconds to collect, can detect men at high risk and spare others unnecessary treatment

Scientists have developed a spit test that could “turn the tide” on prostate cancer worldwide by spotting the disease earlier, detecting where men are at high risk and sparing others unnecessary treatment.

The number of men diagnosed with prostate cancer worldwide is projected to double to 2.9 million a year by 2040, with annual deaths predicted to rise by 85%. It is already the most common form of male cancer in more than 100 countries.

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© Photograph: PBWPIX/Alamy

Boeing’s Starliner capsule poised for second try at first astronaut flight

Boeing's Starliner spacecraft sits on top of a United Launch Alliance Atlas V rocket at Cape Canaveral Space Force Station, Florida.

Enlarge / Boeing's Starliner spacecraft sits on top of a United Launch Alliance Atlas V rocket at Cape Canaveral Space Force Station, Florida. (credit: NASA/Joel Kowsky)

NASA and Boeing officials are ready for a second attempt to launch the first crew test flight on the Starliner spacecraft Saturday from Cape Canaveral Space Force Station, Florida.

Liftoff of Boeing's Starliner capsuled atop a United Launch Alliance Atlas V rocket is set for 12:25 pm EDT (16:25 UTC). NASA commander Butch Wilmore and pilot Suni Williams, both veteran astronauts, will take the Starliner spacecraft on its first trip into low-Earth orbit with a crew on board.

You can watch NASA TV's live coverage of the countdown and launch below.

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FDA’s review of MDMA for PTSD highlights study bias and safety concerns

MDMA is now in the FDA's hands.

Enlarge / MDMA is now in the FDA's hands. (credit: Getty | PYMCA/Avalon)

The safety and efficacy data on the use of MDMA (aka ecstasy) for post-traumatic stress disorder therapy is "challenging to interpret," the Food and Drug Administration said in a briefing document posted Friday. The agency noted significant flaws in the design of the underlying clinical trials as well as safety concerns for the drug, particularly cardiovascular harms.

On Tuesday, June 4, the FDA will convene an advisory committee that will review the evidence and vote on MDMA's efficacy and whether its benefits outweigh its risks. The FDA does not have to follow the committee's recommendations, but it often does. If the FDA subsequently approves MDMA as part of treatment for PTSD, it would mark a significant shift in the federal government's stance on MDMA, as well as psychedelics, generally. Currently, the US Drug Enforcement Administration considers MDMA a Schedule I drug, defined as one with "no currently accepted medical use and a high potential for abuse." It would also offer a new treatment option for patients with PTSD, a disabling psychiatric condition with few treatment options currently.

As Ars has reported previously, the submission of MDMA for approval is based on two clinical trials. The first trial, published in Nature Medicine in 2021, involved 90 participants with moderate PTSD and found that MDMA-assisted psychotherapy significantly improved Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) scores compared with participants who were given psychotherapy along with a placebo. In the second study, published in September in Nature Medicine, the finding held up among 104 participants with moderate or severe PTSD (73 percent had severe PTSD).

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Biomedical Paper Retractions Have Quadrupled in 20 Years

The retraction rate for European biomedical-science papers increased fourfold between 2000 and 2021, a study of thousands of retractions has found. Nature: Two-thirds of these papers were withdrawn for reasons relating to research misconduct, such as data and image manipulation or authorship fraud. These factors accounted for an increasing proportion of retractions over the roughly 20-year period, the analysis suggests. "Our findings indicate that research misconduct has become more prevalent in Europe over the last two decades," write the authors, led by Alberto RuanoâRavina, a public-health researcher at the University of Santiago de Compostela in Spain. Other research-integrity specialists point out that retractions could be on the rise because researchers and publishers are getting better at investigating and identifying potential misconduct. There are more people working to spot errors and new digital tools to screen publications for suspicious text or data. Scholarly publishers have faced increased pressure to clear up the literature in recent years as sleuths have exposed cases of research fraud, identified when peer review has been compromised and uncovered the buying and selling of research articles. Last year saw a record 10,000 papers retracted. Although misconduct is a leading cause of retractions, it is not always responsible: some papers are retracted when authors discover honest errors in their work.

Read more of this story at Slashdot.

Mutations in a non-coding gene associated with intellectual disability

Colored ribbons that represent the molecular structure of a large collection of proteins and RNAs.

Enlarge / The spliceosome is a large complex of proteins and RNAs. (credit: NCBI)

Almost 1,500 genes have been implicated in intellectual disabilities; yet for most people with such disabilities, genetic causes remain unknown. Perhaps this is in part because geneticists have been focusing on the wrong stretches of DNA when they go searching. To rectify this, Ernest Turro—a biostatistician who focuses on genetics, genomics, and molecular diagnostics—used whole genome sequencing data from the 100,000 Genomes Project to search for areas associated with intellectual disabilities.

His lab found a genetic association that is the most common one yet to be associated with neurodevelopmental abnormality. And the gene they identified doesn’t even make a protein.

Trouble with the spliceosome

Most genes include instructions for how to make proteins. That’s true. And yet human genes are not arranged linearly—or rather, they are arranged linearly, but not contiguously. A gene containing the instructions for which amino acids to string together to make a particular protein—hemoglobin, insulin, serotonin, albumin, estrogen, whatever protein you like—is modular. It contains part of the amino acid sequence, then it has a chunk of DNA that is largely irrelevant to that sequence, then a bit more of the protein’s sequence, then another chunk of random DNA, back and forth until the end of the protein. It’s as if each of these prose paragraphs were separated by a string of unrelated letters (but not a meaningful paragraph from a different article).

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Men and other mammals live longer if they are castrated, says researcher

Cat Bohannon tells Hay festival audience it is not known why men go through life ‘smuggling two little death nuggets’

Whether it is the fountain of youth or the elixir of life, men have travelled the world looking for the key to increasing their longevity.

They should be looking a bit closer to home, according to one leading researcher – although after they do, they might end up taking the years God intended for them.

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© Photograph: Annabel Clark/The Guardian

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© Photograph: Annabel Clark/The Guardian

Six planets to appear in alignment next week in rare celestial parade

Mercury, Mars, Jupiter, Saturn, Neptune and Uranus will be visible but viewers may need some equipment to see them clearly

Stargazers are in with a chance of a celestial treat on Monday with six planets appearing in alignment.

Mercury, Mars, Jupiter, Saturn, Neptune and Uranus will take part in the parade – which occurs when planets gather on the same side of the sun.

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© Photograph: Steve Allen Photography/Getty Images

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© Photograph: Steve Allen Photography/Getty Images

Trial results for new lung cancer drug are ‘off the charts’, say doctors

More than half of patients with advanced forms of disease who took lorlatinib were still alive after five years with no progression

Doctors are hailing “off the chart” trial results that show a new drug stopped lung cancer advancing for longer than any other treatment in medical history.

Lung cancer is the world’s leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor.

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© Photograph: da-kuk/Getty Images

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© Photograph: da-kuk/Getty Images

Rocket Report: North Korean rocket explosion; launch over Chinese skyline

A sea-borne variant of the commercial Ceres 1 rocket lifts off near the coast of Rizhao, a city of 3 million in China's Shandong province.

Enlarge / A sea-borne variant of the commercial Ceres 1 rocket lifts off near the coast of Rizhao, a city of 3 million in China's Shandong province. (credit: VCG via Getty Images)

Welcome to Edition 6.46 of the Rocket Report! It looks like we will be covering the crew test flight of Boeing's Starliner spacecraft and the fourth test flight of SpaceX's giant Starship rocket over the next week. All of this is happening as SpaceX keeps up its cadence of flying multiple Starlink missions per week. The real stars are the Ars copy editors helping make sure our stories don't use the wrong names.

As always, we welcome reader submissions, and if you don't want to miss an issue, please subscribe using the box below (the form will not appear on AMP-enabled versions of the site). Each report will include information on small-, medium-, and heavy-lift rockets as well as a quick look ahead at the next three launches on the calendar.

Another North Korean launch failure. North Korea's latest attempt to launch a rocket with a military reconnaissance satellite ended in failure due to the midair explosion of the rocket during the first-stage flight this week, South Korea's Yonhap News Agency reports. Video captured by the Japanese news organization NHK appears to show the North Korean rocket disappearing in a fireball shortly after liftoff Monday night from a launch pad on the country's northwest coast. North Korean officials acknowledged the launch failure and said the rocket was carrying a small reconnaissance satellite named Malligyong-1-1.

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Mushroom-growing boom could cause biodiversity crisis, warn UK experts

RHS fears non-native fungi could alter microbiology of soil when grown in gardens or disposed of in compost heaps

A boom in the popularity of mushroom-growing at home could lead to a biodiversity disaster, UK garden experts have warned.

There has been a rise in the number of people growing mushrooms in their gardens, and this year, the RHS Chelsea flower show’s plant of the year award included a mushroom – the tarragon oyster mushroom, thought to be found only in the British Isles – in its shortlist for the first time, despite it being a fungus, not a plant.

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© Photograph: Jennifer Gauld/Getty Images/iStockphoto

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© Photograph: Jennifer Gauld/Getty Images/iStockphoto

What are cancer vaccines and have scientists finally found a cure?

The NHS in England is recruiting for the first large-scale trial of its kind, with hopes high that the personalised jabs could be a gamechanger

Cancer vaccines are a form of immunotherapy. Unlike vaccines that protect from an infection, such as the Covid-19 jab, cancer vaccines treat people who already have the disease. They are designed to help the patient’s immune system recognise and then kill cancer cells – and prevent them from coming back.

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© Illustration: Sigrid Gombert/Science Photo Library RF

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© Illustration: Sigrid Gombert/Science Photo Library RF

NHS patients in England to be offered trials for world-first cancer vaccine

Jab personalised for individual’s tumours hailed as ‘gamechanger’ amid high hopes of stopping disease returning

Thousands of patients in England are to be fast-tracked into groundbreaking trials of personalised cancer vaccines in a revolutionary world-first NHS “matchmaking” scheme to save lives.

The gamechanging jabs, which aim to provide a permanent cure, are custom-built for each patient in just a few weeks. They are tailored to the individual’s tumours and work by telling their body to hunt and kill any cancer cells and prevent the disease from coming back.

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© Photograph: University Hospitals Birmingham NHS Foundation Trust

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© Photograph: University Hospitals Birmingham NHS Foundation Trust

Key misinformation “superspreaders” on Twitter: Older women

An older woman holding a coffee mug and staring at a laptop on her lap.

Enlarge (credit: Alistair Berg)

Misinformation is not a new problem, but there are plenty of indications that the advent of social media has made things worse. Academic researchers have responded by trying to understand the scope of the problem, identifying the most misinformation-filled social media networks, organized government efforts to spread false information, and even prominent individuals who are the sources of misinformation.

All of that's potentially valuable data. But it skips over another major contribution: average individuals who, for one reason or another, seem inspired to spread misinformation. A study released today looks at a large panel of Twitter accounts that are associated with US-based voters (the work was done back when X was still Twitter). It identifies a small group of misinformation superspreaders, which represent just 0.3 percent of the accounts but are responsible for sharing 80 percent of the links to fake news sites.

While you might expect these to be young, Internet-savvy individuals who automate their sharing, it turns out this population tends to be older, female, and very, very prone to clicking the "retweet" button.

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Third human case of bird flu from cows—this one with respiratory symptoms

Holstein cows at a dairy farm.

Enlarge / Holstein cows at a dairy farm. (credit: Getty | John Carl D'Annibale)

Another dairy farm worker in Michigan has been infected with avian influenza virus, state and federal health officials reported Thursday.

The case marks the third time the outbreak of bird flu in milking cows is known to have spilled over to a human. The dairy farm worker in Michigan, like the others, had close contact with H5N1-infected dairy cows, suggesting another case of cow-to-human transmission.

But the case reported today is notable for being the first one involving respiratory symptoms. In the first two cases, the dairy workers (one in Texas, the other in Michigan) reported only eye infections (conjunctivitis). This third case—also in Michigan but from a different farm—reported upper respiratory symptoms, including cough, congestion, and sore throat, as well as eye discomfort and watery discharge, but not conjunctivitis. The worker was given an antiviral (Tamiflu) and is said to be recovering. No other workers on the farm have shown symptoms, and the worker's household contacts are being monitored.

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$10m prize launched for team that can truly talk to the animals

AI expected to help researchers unlock two-way communication, say team that includes Tel Aviv University

In the Dr Dolittle books and films, the ability to “talk to the animals” captured the imagination. Now scientists are being offered a $10m prize to create real conversations.

The Coller Dolittle Challenge for Interspecies Two-Way Communication has been launched by the Jeremy Coller Foundation and Tel Aviv University. While the use of AI is not obligatory, the team say the technology can boost almost all proposals.

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© Photograph: Rover.com

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© Photograph: Rover.com

Modern lives are messing up menstrual cycles—earlier starts, more irregularity

Panty liners, hygienic tampons, and sanitary pads.

Enlarge / Panty liners, hygienic tampons, and sanitary pads. (credit: Getty | LOU BENOIST)

People in the US are starting their menstrual cycles earlier and experiencing more irregularities, both of which raise the risk of a host of health problems later in life, according to an Apple women’s health study looking at data from over 70,000 menstruating iPhone users born between 1950 and 2005.

The mean age of people's first period fell from 12.5 years in participants born between 1950 and 1969 to 11.9 years in participants born between 2000 and 2005, with a steady decline in between, the study found. There were also notable changes in the extremes—between 1950 and 2005, the percentage of people who started their periods before age 11 rose from 8.6 percent to 15.5 percent. And the percentage of people who started their periods late (at age 16 or above) dropped from 5.5 percent to 1.7 percent.

In addition to periods shifting to earlier starting ages, menstrual cycles also appeared to become more irregular. For this, researchers looked at how quickly people settled into a regular cycle after the start of their period. Between 1950 and 2005, the percentage of people obtaining regularity within two years fell from 76.3 percent to 56 percent.

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Fracking wastewater has “shocking” amount of clean-energy mineral lithium

fracking operation in Pennsylvania

Enlarge / A hydro-fracking drilling pad for oil and gas operates October 26, 2017 in Robinson Township, Pennsylvania. (credit: Robert Nickelsberg/Getty Images)

In 2007, a geoscientist at Penn State named Terry Engelder calculated that Pennsylvania could be sitting on more than 50 trillion cubic feet of accessible natural gas deposits. Engelder later revised his calculation upward, to 489 trillion cubic feet, enough to meet US natural gas demand for 18 years. These massive numbers set off the fracking boom in Pennsylvania, leading to drilling across the state. Since the rush began, there have been 13,000 unconventional wells drilled in Pennsylvania.

Now, a new “astounding” calculation has caught the attention of the gas industry: A study from researchers at the National Energy Technology Laboratory shows the wastewater produced by Pennsylvania’s unconventional wells could contain enough lithium to meet 38 to 40 percent of current domestic consumption. Lithium is a critical mineral that’s an “essential component” of many clean energy technologies, including batteries for electric vehicles. 

The study used chemical and production compliance data from the Pennsylvania Department of Environmental Protection to estimate that approximately 1,160 metric tons of lithium per year could be extracted from this produced water, which is a combination of fluids used for fracking and water from natural formations underground that returns to the surface during the drilling process. The lithium in Pennsylvania’s produced water likely comes from ancient volcanoes that were erupting at the time the natural gas deposits were being formed. This volcanic ash contained lithium that eventually seeped into the water underground.

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Meet the Chinese army’s latest weapon: the gun-toting dog

China shows off mechanical canine with an automatic rifle on its back at joint military drills with Cambodia

The Chinese army has debuted its latest weapon: a gun-toting robotic dog.

The mechanical canine, which has an automatic rifle on its back, was front and centre of recent joint military drills with Cambodia, according to footage from the state broadcaster CCTV.

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© Photograph: Tang Chhin Sothy/AFP/Getty Images

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© Photograph: Tang Chhin Sothy/AFP/Getty Images

Scientists have discovered a 50,000-year-old herpes virus – and perhaps how modern humans came to rule the world | Jonathan Kennedy

Revolutionary ancient DNA evidence indicates that Homo sapiens finished off Neanderthals through deadly infectious diseases

Less than a decade ago, the American anthropologist James C Scott described infectious diseases as the “loudest silence” in the prehistoric archaeological record. Epidemics must have devastated human societies in the distant past and changed the course of history, but, Scott lamented, the artefacts left behind reveal nothing about them.

Over the last few years, the silence has been shattered by pioneering research that analyses microbial DNA extracted from very old human skeletons. The latest example of this is a groundbreaking study that identified three viruses in 50,000-year-old Neanderthal bones. These pathogens still afflict modern humans: adenovirus, herpesvirus and papillomavirus cause the common cold, cold sores, and genital warts and cancer, respectively. The discovery may help us resolve the greatest mystery of the Palaeolithic era: what caused the extinction of Neanderthals.

Jonathan Kennedy teaches politics and global health at Queen Mary University of London and is the author of Pathogenesis: How Germs Made History

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© Photograph: Jens Schlueter/Getty Images

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© Photograph: Jens Schlueter/Getty Images

AI brain map could help demystify Alzheimer’s and autism

Florida scientists use AI and virtual reality to create 3D renderings of brain formations of mice, whose neuron types are like humans’

Neuroscientists at a Florida university have pioneered a technologically advanced method of brain mapping they believe can help demystify Alzheimer’s disease, autism and related disorders, and offer hope of more effective treatments for traumatic brain injuries.

A team at the University of South Florida’s (USF) auditory development and connectomics laboratory is using virtual reality (VR) and artificial intelligence to create a high-definition visual timeline of the journey of billions of neurons in the developing brains of newborn mice.

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© Photograph: University of South Florida

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© Photograph: University of South Florida

Bizarre armor from Mycenaean Greece turns out to have been effective

Two images of a person wearing unusual armor that covers his torso in bands of metal, with a deep collar and high helmet.

Enlarge / Armor based on the Dendra artifact being tested. (credit: Andreas Flouris and Stavros Petmezas)

The Dendra armor, one of the oldest suits of bronze armor ever found, had been considered a purely ceremonial piece. It seemed impossible to use in battle due to its cumbersome design.

It took over a decade of research, elaborate numerical models, and 13 Greek marines fighting in it from dawn till dusk to prove it was surprisingly good at its job, despite its odd appearance. “This made the Mycenaean warriors some of the best equipped in the Eastern Mediterranean in the Late Bronze Age,” says professor Andreas Flouris, a researcher at the University of Thessaly, who led the study.

Mycenaean Conquests

“The Mycenaeans were an ancient Greek civilization that flourished during the late Bronze Age, roughly from 1600 BC to 1100 BC,” explains Ken Wardle, an archeologist at the University of Birmingham and co-author of the study. With their power centered around major cities like Mycenae, Thebes, Tiryns, and Pylos, the Mycenaeans peaked between 1400 BCE and 1200 BCE, when they occupied much of mainland Greece and gained influence over Aegean islands and Asia Minor.

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Election risks, safety summits and Scarlett Johansson: the week in AI – podcast

It’s been a busy week in the world of artificial intelligence. OpenAI found itself in hot water with Scarlett Johansson after launching its new chatbot, Sky, drawing comparisons to the Hollywood star’s character in the sci-fi film Her. In South Korea, the second global AI summit took place, and a report from the Alan Turing Institute explored how AI could influence elections. The Guardian’s UK technology editor, Alex Hern, tells Madeleine Finlay about what’s been happening

Clips: Today, BBC News

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© Photograph: Jason Redmond/AFP/Getty Images

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© Photograph: Jason Redmond/AFP/Getty Images

Europe seeks to emulate NASA’s revolutionary commercial cargo program

A rendering of the European cargo reentry vehicle proposed by Thales Alenia Space.

Enlarge / A rendering of the European cargo reentry vehicle proposed by Thales Alenia Space. (credit: Thales Alecia Space)

The European Space Agency has awarded initial contracts to a German-based startup and one of the continent's established aerospace companies to develop spacecraft to ferry cargo to and from space stations in low-Earth orbit.

ESA announced the two 25 million euro ($27 million) contracts May 22. The Exploration Company, co-located in France and Germany, and Thales Alenia Space of Italy beat out four other companies in the competition for ESA funding through the LEO Cargo Return Service program.

These contracts will run for two years, until June 2026. In this first phase of the program, The Exploration Company and Thales Alenia Space will refine their concepts, mature technologies, and focus on requirements for their cargo vehicles. ESA plans to award contracts for the second phase of the LEO Cargo Return Service program in 2026, eyeing a round-trip demonstration flight to the International Space Station (ISS) in 2028.

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Climate and health benefits of wind and solar dwarf all subsidies

Wind turbines in front of a sunrise, with their blades blurred due to their motion.

Enlarge (credit: Ashley Cooper)

When used to generate power or move vehicles, fossil fuels kill people. Particulates and ozone resulting from fossil fuel burning cause direct health impacts, while climate change will act indirectly. Regardless of the immediacy, premature deaths and illness prior to death are felt through lost productivity and the cost of treatments.

Typically, you see the financial impacts quantified when the EPA issues new regulations, as the health benefits of limiting pollution typically dwarf the costs of meeting new standards. But some researchers from Lawrence Berkeley National Lab have now done similar calculations—but focusing on the impact of renewable energy. Wind and solar, by displacing fossil fuel use, are acting as a form of pollution control and so should produce similar economic benefits.

Do they ever. The researchers find that, in the US, wind and solar have health and climate benefits of over $100 for every Megawatt-hour produced, for a total of a quarter-trillion dollars in just the last four years. This dwarfs the cost of the electricity they generate and the total of the subsidies they received.

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Alpacas in Idaho test positive for H5N1 bird flu in another world first

Suri alpacas on a farm in Pennsylvania.

Enlarge / Suri alpacas on a farm in Pennsylvania. (credit: Getty | Susan L. Angstadt)

Four backyard alpacas in southern Idaho have tested positive for highly pathogenic avian influenza (HPAI) H5N1, marking the first time bird flu has been detected in members of the fleecy camelid family, according to the US Department of Agriculture.

On Tuesday, the USDA announced that the agency's National Veterinary Services Laboratories confirmed the infection on a farm in Jerome County on May 16. While the infections are a first for the spitting llama relatives, the USDA said they weren't particularly surprising. The alpacas were in close contact with HPAI-infected poultry on the farm, which were "depopulated" this month. Of 18 alpacas on the affected farm, only four were found to be infected. There were no deaths documented, according to a report the USDA submitted to the World Organization for Animal Health.

Genomic sequencing indicates that the H5N1 virus infecting the alpacas (B3.13) matches both the virus currently circulating among US dairy cows and the virus that infected birds on the farm.

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Babbling babies may be warming up for speech, say scientists

Squeals and growls tend to occur in groups, finds study of infants aged up to 13 months

It might sound like a stream of jolly nonsense, but the peculiar sounds babies produce could be an attempt to practise the vocal control necessary for speech, researchers have suggested.

A study analysing the sounds made by infants during their first year of life has found squeals and growls tend to occur in groups.

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© Photograph: David Sacks/Getty Images

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© Photograph: David Sacks/Getty Images

‘Virtually complete’ Stegosaurus fossil to be auctioned at Sotheby’s geek week

The 11ft tall and 20ft long fossil, nicknamed Apex, could fetch up to $6m as it’s celebrated as ‘one of the best unearthed’

The largest and most complete Stegosaurus fossil ever found is expected to fetch up to $6m (£4.7m) when it is sold as the star lot in Sotheby’s “geek week” auction this summer.

At 11ft (3.4 metres) tall and more than 20ft long the “virtually complete” fossil, which has been nicknamed “Apex”, is more than 30% larger than “Sophie”, the previously most intact stegosaurus specimen which was on display in London’s Natural History Museum.

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© Photograph: Matthew Sherman/Sotheby’s

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© Photograph: Matthew Sherman/Sotheby’s

Americans have demonized drugs for decades. Now we’re doing them every day

Regular drug use – from caffeine to psychedelics – has become a fundamental part of modern life. A first-person Guardian US series explores America’s shifting relationship with mind-altering substances

There are plenty of fanciful, far-out theories of how the whole of civilization emerged from drug use – like the theory that the consumption of proto-LSD in ancient Greek cults catalyzed modern philosophy; or the theory that various religious traditions have their roots in revelations occasioned by the body processing stores of endogenous DMT; or the theory that the evolution of Homo erectus into Homo sapiens, and the corresponding emergence of consciousness as a phenomenon, was driven, some hundred thousand years ago, by the consumption of psychedelic mushrooms.

But you don’t need to delve that deep into the nether regions of the psychedelic dark web to believe that the world as we know it – where we think and feel and transact business and eat and sleep and read the newspaper – is built, at a fundamental, inextricable level, on a drug. That drug is caffeine.

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© Illustration: Mona Chalabi/The Guardian

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© Illustration: Mona Chalabi/The Guardian

Ars Live: How profitable is Starlink? We dig into the details of satellite Internet.

A stack of 60 Starlink satellites being launched into space, with Earth in the background.

Enlarge / A stack of 60 Starlink satellites launched in 2019. (credit: SpaceX / Flickr)

SpaceX began launching operational Starlink satellites five years ago this month. Since then, the company has been rapidly developing its constellation of broadband satellites in low-Earth orbit. SpaceX has now launched about 6,000 satellites with its Falcon 9 rocket and has delivered on its promise to provide fast Internet around the world. Today, the company is the largest satellite operator in the world by a factor of 10.

But is this massive enterprise to deliver Internet from space profitable?

According to a new report by Quilty Space, the answer is yes. Quilty built a model to assess Starlink's profitability. First, the researchers assessed revenue. The firm estimates this will grow to $6.6 billion in 2024, up from essentially zero just four years ago. In addition to rapidly growing its subscriber base of about 3 million, SpaceX has also managed to control costs. Based upon its model, therefore, Quilty estimates that Starlink's free cash flow from the business will be about $600 million this year.

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Our only mission at Venus may have just gone dark

Processed image of Venus captured by the Akatsuki spacecraft.

Enlarge / Processed image of Venus captured by the Akatsuki spacecraft. (credit: JAXA/ISAS/DARTS/Kevin M. Gill)

JAXA, the Japanese space agency, confirmed Wednesday that it has lost communication with its Akatsuki spacecraft in orbit around Venus.

In its update, the space agency said it failed to establish communications in late April after the spacecraft had difficulty maintaining its attitude. This likely means there is some sort of thruster issue on the spacecraft that is preventing it from being able to orient itself back toward Earth.

"Since then, we have implemented various measures to restore service, but communication has not yet been restored," the agency stated. "We are currently working on restoring communication." JAXA added that it will announce further actions, if any, as soon as they've been decided upon.

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Daily Telescope: See carbon dioxide sublimating on Mars

A field of sand dunes in the Martian springtime.

A field of sand dunes in the Martian springtime. (credit: NASA/JPL-Caltech/University of Arizona)

Welcome to the Daily Telescope. There is a little too much darkness in this world and not enough light, a little too much pseudoscience and not enough science. We'll let other publications offer you a daily horoscope. At Ars Technica, we're going to take a different route, finding inspiration from very real images of a universe that is filled with stars and wonder.

Good morning. It's May 29, and today's photo comes from NASA's Mars Reconnaissance Orbiter, which is, you guessed it, in orbit around Mars.

The image shows an area of sand dunes on Mars in the springtime, when carbon dioxide frost is sublimating into the air. According to NASA, the pattern of dark spots is due to the fact that the sublimation process is not uniform.

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