How Did a Heart Drug With So Much Promise Fall So Flat? NYT: Science By: Gina Kolata 11 September 2026 at 12:31 Cardiologists are struggling to figure out why a drug that should have prevented heart attacks didnβt work at all. Β© Science Photo Library, via AlamyAn illustration of a lipoprotein A particle. Scientists are asking themselves: If Lp(a) is a marker, what is it marking? Is there another cause of heart disease that no one has thought of?