An anonymous reader quotes a report from CBS News: Richard "Rick" Slayman, the first human to receive a genetically modified pig kidney transplant, has died almost two months after the procedure. Slayman, who had end-stage kidney disease, underwent the transplant in March at Massachusetts General Hospital in Boston at age 62. The hospital said in a statement on Saturday that there was "no indication" that his death was the result of the transplant. The transplant surgeon had said he hoped the transplant would function for at least two years. "The Mass General transplant team is deeply saddened at the sudden passing of Mr. Rick Slayman," read the hospital statement. "Mr. Slayman will forever be seen as a beacon of hope to countless transplant patients worldwide and we are deeply grateful for his trust and willingness to advance the field of xenotransplantation." The surgery was a milestone for the field of xenotransplantation -- the transplant of organs from one species to another -- as a way to alleviate the organ shortage for people who need transplants. The effort to genetically modify animal organs is in hopes that the human body will not reject the foreign tissue. NPR notes that there are more than 100,000 people in the U.S. on the waitlist for organs.

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Brian Shelton's type 1 diabetes was treated with an infusion of insulin-producing pancreas cells (grown from stem cells). In 2021, the New York Times reported: Now his body automatically controls its insulin and blood sugar levels. Shelton, now 64, may be the first person cured of the disease with a new treatment that has experts daring to hope that help may be coming for many of the 1.5 million Americans suffering from Type 1 diabetes. "It's a whole new life," Shelton said. Diabetes experts were astonished but urged caution. The study is continuing and will take five years, involving 17 people with Type 1 diabetes. "By fall 2023, three patients, including Shelton, had achieved insulin independence by day 180 post-transplant," MedScape reported (in January of 2024): In the phase 1/2 study, 14 patients with type 1 diabetes and impaired hypoglycemia awareness or recurrent hypoglycemia received portal vein infusions of VX-880 [Vertex Pharmaceutical's pancreatic islet cell replacement therapy] along with standard immunosuppression. As of the last data cut, all 14 patients demonstrated islet cell engraftment and production of endogenous insulin. After more than 90 days of follow-up, 13 of the patients have achieved A1c levels

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An anonymous reader quotes a report from Interesting Engineering: Imagine exploring the intricate world within a single cubic millimeter of human brain tissue. It might seem insignificant, but within that tiny space lies a universe of complexity -- 57,000 individual cells, 230 millimeters of blood vessels, and a staggering 150 million synapses, the junctions where neurons communicate. All this information translates to a mind-boggling 1,400 terabytes of data. That's the kind of groundbreaking achievement researchers from Harvard and Google have just accomplished. Leading the charge at Harvard is Professor Jeff Lichtman, a renowned expert in brain structure. Partnering with Google AI, Lichtman's team has co-created the most detailed 3D reconstruction of a human brain fragment to date. This intricate map, published in Science, offers an unprecedented view of the human temporal cortex, the region responsible for memory and other higher functions. Envision a piece of brain tissue roughly half the size of a rice grain but magnified to reveal every cell and its web of neural connections in vivid detail. This remarkable feat is the culmination of nearly a decade of collaboration between Harvard and Google. Lichtman's expertise in electron microscopy imaging is combined with Google's cutting-edge AI algorithms. [...] The newly published map in Science reveals previously unseen details of brain structure. One such discovery is a rare but powerful set of axons, each connected by up to 50 synapses, potentially influencing a significant number of neighboring neurons. The team also encountered unexpected structures, like a small number of axons forming intricate whorls. Since the sample came from a patient with epilepsy, it's unclear if these formations are specific to the condition or simply uncommon occurrences.

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Ancient Slashdot reader jd shares a report from The Guardian: Neuralink's first attempt at implanting its chip in a human being's skull hit an unexpected setback after the device began to detach from the patient's brain, the company revealed on Wednesday. The patient, Noland Arbaugh, underwent surgery in February to attach a Neuralink chip to his brain, but the device's functionality began to decrease within the month after his implant. Some of the device's threads, which connect the miniature computer to the brain, had begun to retract. Neuralink did not disclose why the device partly retracted from Arbaugh's brain, but stated in a blog post that its engineers had refined the implant and restored functionality. The decreased capabilities did not appear to endanger Arbaugh, and he could still use the implant to play a game of chess on a computer using his thoughts, according to the Wall Street Journal, which first broke the news of the issue with the chip. The possibility of removing the implant was considered after the detachment came to light, the Journal reported. [...] Arbaugh praised the implant during a demonstration in March and said that it had "already changed his life," while also stating that it had not been perfect and they "have run into some issues."

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AstraZeneca said on Tuesday it had initiated the worldwide withdrawal of its COVID-19 vaccine due to a "surplus of available updated vaccines" since the pandemic. From a report: The company also said it would proceed to withdraw the vaccine Vaxzevria's marketing authorizations within Europe. "As multiple, variant COVID-19 vaccines have since been developed there is a surplus of available updated vaccines," the company said, adding that this had led to a decline in demand for Vaxzevria, which is no longer being manufactured or supplied. According to media reports, the Anglo-Swedish drugmaker has previously admitted in court documents that the vaccine causes side-effects such as blood clots and low blood platelet counts.

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For the first time, scientists observed a primate in the wild treating a wound with a plant that has medicinal properties.

Some researchers said the advice did not go far enough. The panel also declined to recommend extra scans for women with dense breast tissue.

© Michael Hanschke/picture alliance, via Getty Images

Animal-welfare science tries to get inside the minds of a huge range of species — in order to help improve their lives.

Officials have shared little information, saying the outbreak was limited. But asymptomatic cows in North Carolina have changed the assessment.

© Jim Vondruska/Reuters

Mammography can miss tumors in women with dense breasts, so their doctors often include ultrasound or M.R.I. scans. Patients often wind up paying the bill.

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We want to hear from pet owners about their experiences taking their animals to the vet, and how they paid for their animals’ care.

© Jenna Schoenefeld for The New York Times

The New England Journal of Medicine published an article condemning its own record during World War II.

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The data privacy company Onerep.com bills itself as a Virginia-based service for helping people remove their personal information from almost 200 people-search websites. However, an investigation into the history of onerep.com finds this company is operating out of Belarus and Cyprus, and that its founder has launched dozens of people-search services over the years.

Onerep’s “Protect” service starts at $8.33 per month for individuals and $15/mo for families, and promises to remove your personal information from nearly 200 people-search sites. Onerep also markets its service to companies seeking to offer their employees the ability to have their data continuously removed from people-search sites.

Customer case studies published on onerep.com state that it struck a deal to offer the service to employees of Permanente Medicine, which represents the doctors within the health insurance giant Kaiser Permanente. Onerep also says it has made inroads among police departments in the United States.

But a review of Onerep’s domain registration records and that of its founder reveal a different side to this company. Onerep.com says its founder and CEO is Dimitri Shelest from Minsk, Belarus, as does Shelest’s profile on LinkedIn. Historic registration records indexed by DomainTools.com say Mr. Shelest was a registrant of onerep.com who used the email address dmitrcox2@gmail.com.

A search in the data breach tracking service Constella Intelligence for the name Dimitri Shelest brings up the email address dimitri.shelest@onerep.com. Constella also finds that Dimitri Shelest from Belarus used the email address d.sh@nuwber.com, and the Belarus phone number +375-292-702786.

Nuwber.com is a people search service whose employees all appear to be from Belarus, and it is one of dozens of people-search companies that Onerep claims to target with its data-removal service. Onerep.com’s website disavows any relationship to Nuwber.com, stating quite clearly, “Please note that OneRep is not associated with Nuwber.com.”

However, there is an abundance of evidence suggesting Mr. Shelest is in fact the founder of Nuwber. Constella found that Minsk telephone number (375-292-702786) has been used multiple times in connection with the email address dmitrcox@gmail.com. Recall that Onerep.com’s domain registration records in 2018 list the email address dmitrcox2@gmail.com.

It appears Mr. Shelest sought to reinvent his online identity in 2015 by adding a “2” to his email address. The Belarus phone number tied to Nuwber.com shows up in the domain records for comversus.com, and DomainTools says this domain is tied to both dmitrcox@gmail.com and dmitrcox2@gmail.com. Other domains that mention both email addresses in their WHOIS records include careon.me, docvsdoc.com, dotcomsvdot.com, namevname.com, okanyway.com and tapanyapp.com.

A search in DomainTools for the email address dmitrcox@gmail.com shows it is associated with the registration of at least 179 domain names, including dozens of mostly now-defunct people-search companies targeting citizens of Argentina, Brazil, Canada, Denmark, France, Germany, Hong Kong, Israel, Italy, Japan, Latvia and Mexico, among others.

Those include nuwber.fr, a site registered in 2016 which was identical to the homepage of Nuwber.com at the time. DomainTools shows the same email and Belarus phone number are in historic registration records for nuwber.at, nuwber.ch, and nuwber.dk (all domains linked here are to their cached copies at archive.org, where available).

Update, March 21, 11:15 a.m. ET: Mr. Shelest has provided a lengthy response to the findings in this story. In summary, Shelest acknowledged maintaining an ownership stake in Nuwber, but said there was “zero cross-over or information-sharing with OneRep.” Mr. Shelest said any other old domains that may be found and associated with his name are no longer being operated by him.

“I get it,” Shelest wrote. “My affiliation with a people search business may look odd from the outside. In truth, if I hadn’t taken that initial path with a deep dive into how people search sites work, Onerep wouldn’t have the best tech and team in the space. Still, I now appreciate that we did not make this more clear in the past and I’m aiming to do better in the future.” The full statement is available here (PDF).

Original story:

Historic WHOIS records for onerep.com show it was registered for many years to a resident of Sioux Falls, SD for a completely unrelated site. But around Sept. 2015 the domain switched from the registrar GoDaddy.com to eNom, and the registration records were hidden behind privacy protection services. DomainTools indicates around this time onerep.com started using domain name servers from DNS provider constellix.com. Likewise, Nuwber.com first appeared in late 2015, was also registered through eNom, and also started using constellix.com for DNS at nearly the same time.

Listed on LinkedIn as a former product manager at OneRep.com between 2015 and 2018 is Dimitri Bukuyazau, who says their hometown is Warsaw, Poland. While this LinkedIn profile (linkedin.com/in/dzmitrybukuyazau) does not mention Nuwber, a search on this name in Google turns up a 2017 blog post from privacyduck.com, which laid out a number of reasons to support a conclusion that OneRep and Nuwber.com were the same company.

“Any people search profiles containing your Personally Identifiable Information that were on Nuwber.com were also mirrored identically on OneRep.com, down to the relatives’ names and address histories,” Privacyduck.com wrote. The post continued:

“Both sites offered the same immediate opt-out process. Both sites had the same generic contact and support structure. They were – and remain – the same company (even PissedConsumer.com advocates this fact: https://nuwber.pissedconsumer.com/nuwber-and-onerep-20160707878520.html).”

“Things changed in early 2016 when OneRep.com began offering privacy removal services right alongside their own open displays of your personal information. At this point when you found yourself on Nuwber.com OR OneRep.com, you would be provided with the option of opting-out your data on their site for free – but also be highly encouraged to pay them to remove it from a slew of other sites (and part of that payment was removing you from their own site, Nuwber.com, as a benefit of their service).”

Reached via LinkedIn, Mr. Bukuyazau declined to answer questions, such as whether he ever worked at Nuwber.com. However, Constella Intelligence finds two interesting email addresses for employees at nuwber.com: d.bu@nuwber.com, and d.bu+figure-eight.com@nuwber.com, which was registered under the name “Dzmitry.”

PrivacyDuck’s claims about how onerep.com appeared and behaved in the early days are not readily verifiable because the domain onerep.com has been completely excluded from the Wayback Machine at archive.org. The Wayback Machine will honor such requests if they come directly from the owner of the domain in question.

Still, Mr. Shelest’s name, phone number and email also appear in the domain registration records for a truly dizzying number of country-specific people-search services, including pplcrwlr.in, pplcrwlr.fr, pplcrwlr.dk, pplcrwlr.jp, peeepl.br.com, peeepl.in, peeepl.it and peeepl.co.uk.

The same details appear in the WHOIS registration records for the now-defunct people-search sites waatpp.de, waatp1.fr, azersab.com, and ahavoila.com, a people-search service for French citizens.

A search on the email address dmitrcox@gmail.com suggests Mr. Shelest was previously involved in rather aggressive email marketing campaigns. In 2010, an anonymous source leaked to KrebsOnSecurity the financial and organizational records of Spamit, which at the time was easily the largest Russian-language pharmacy spam affiliate program in the world.

Spamit paid spammers a hefty commission every time someone bought male enhancement drugs from any of their spam-advertised websites. Mr. Shelest’s email address stood out because immediately after the Spamit database was leaked, KrebsOnSecurity searched all of the Spamit affiliate email addresses to determine if any of them corresponded to social media accounts at Facebook.com (at the time, Facebook allowed users to search profiles by email address).

That mapping, which was done mainly by generous graduate students at my alma mater George Mason University, revealed that dmitrcox@gmail.com was used by a Spamit affiliate, albeit not a very profitable one. That same Facebook profile for Mr. Shelest is still active, and it says he is married and living in Minsk [Update, Mar. 16: Mr. Shelest’s Facebook account is no longer active].

Scrolling down Mr. Shelest’s Facebook page to posts made more than ten years ago show him liking the Facebook profile pages for a large number of other people-search sites, including findita.com, findmedo.com, folkscan.com, huntize.com, ifindy.com, jupery.com, look2man.com, lookerun.com, manyp.com, peepull.com, perserch.com, persuer.com, pervent.com, piplenter.com, piplfind.com, piplscan.com, popopke.com, pplsorce.com, qimeo.com, scoutu2.com, search64.com, searchay.com, seekmi.com, selfabc.com, socsee.com, srching.com, toolooks.com, upearch.com, webmeek.com, and many country-code variations of viadin.ca (e.g. viadin.hk, viadin.com and viadin.de).

Domaintools.com finds that all of the domains mentioned in the last paragraph were registered to the email address dmitrcox@gmail.com.

Mr. Shelest has not responded to multiple requests for comment. KrebsOnSecurity also sought comment from onerep.com, which likewise has not responded to inquiries about its founder’s many apparent conflicts of interest. In any event, these practices would seem to contradict the goal Onerep has stated on its site: “We believe that no one should compromise personal online security and get a profit from it.”

Max Anderson is chief growth officer at 360 Privacy, a legitimate privacy company that works to keep its clients’ data off of more than 400 data broker and people-search sites. Anderson said it is concerning to see a direct link between between a data removal service and data broker websites.

“I would consider it unethical to run a company that sells people’s information, and then charge those same people to have their information removed,” Anderson said.

Last week, KrebsOnSecurity published an analysis of the people-search data broker giant Radaris, whose consumer profiles are deep enough to rival those of far more guarded data broker resources available to U.S. police departments and other law enforcement personnel.

That story revealed that the co-founders of Radaris are two native Russian brothers who operate multiple Russian-language dating services and affiliate programs. It also appears many of the Radaris founders’ businesses have ties to a California marketing firm that works with a Russian state-run media conglomerate currently sanctioned by the U.S. government.

KrebsOnSecurity will continue investigating the history of various consumer data brokers and people-search providers. If any readers have inside knowledge of this industry or key players within it, please consider reaching out to krebsonsecurity at gmail.com.

Update, March 15, 11:35 a.m. ET: Many readers have pointed out something that was somehow overlooked amid all this research: The Mozilla Foundation, the company that runs the Firefox Web browser, has launched a data removal service called Mozilla Monitor that bundles OneRep. That notice says Mozilla Monitor is offered as a free or paid subscription service.

“The free data breach notification service is a partnership with Have I Been Pwned (“HIBP”),” the Mozilla Foundation explains. “The automated data deletion service is a partnership with OneRep to remove personal information published on publicly available online directories and other aggregators of information about individuals (“Data Broker Sites”).”

In a statement shared with KrebsOnSecurity.com, Mozilla said they did assess OneRep’s data removal service to confirm it acts according to privacy principles advocated at Mozilla.

“We were aware of the past affiliations with the entities named in the article and were assured they had ended prior to our work together,” the statement reads. “We’re now looking into this further. We will always put the privacy and security of our customers first and will provide updates as needed.”