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Bringing the "functionally extinct" American chestnut back from the dead

12 February 2026 at 14:00

Very few people alive today have seen the Appalachian forests as they existed a century ago. Even as state and national parks preserved ever more of the ecosystem, fungal pathogens from Asia nearly wiped out one of the dominant species of these forests, the American chestnut, killing an estimated 3 billion trees. While new saplings continue to sprout from the stumps of the former trees, the fungus persists, killing them before they can seed a new generation.

But thanks in part to trees planted in areas where the two fungi don't grow well, the American chestnut isn't extinct. And efforts to revive it in its native range have continued, despite the long generation times needed to breed resistant trees. In Thursday's issue of Science, researchers describe their efforts to apply modern genomic techniques and exhaustive testing to identify the best route to restoring chestnuts to their native range.

Multiple paths to restoration

While the American chestnut is functionally extinctβ€”it's no longer a participant in the ecosystems it once dominatedβ€”it's most certainly not extinct. Two Asian fungi that have killed it off in its native range; one causes chestnut blight, while a less common pathogen causes a root rot disease. Both prefer warmer, humid environments and persist there because they can grow asymptomatically on distantly related trees, such as oaks. Still, chestnuts planted outside the species' original rangeβ€”primarily in drier areas of western North Americaβ€”have continued to thrive.

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Β© Teresa Lett

Custom machine kept man alive without lungs for 48 hours

29 January 2026 at 12:26

Humans can’t live without lungs. And yet for 48 hours, in a surgical suite at Northwestern University, a 33-year-old man lived with an empty cavity in his chest where his lungs used to be. He was kept alive by a custom-engineered artificial device that represented a desperate last-ditch effort by his doctors. The custom hardware solved a physiological puzzle that has made bilateral pneumonectomy, the removal of both lungs, extremely risky before now.

The artificial lung system was built by the team of Ankit Bharat, a surgeon and researcher at Northwestern. It successfully kept a critically ill patient alive long enough to enable a double lung transplant, temporarily replacing his entire pulmonary system with a synthetic surrogate. The system creates a blueprint for saving people previously considered beyond hope by transplant teams.

Melting lungs

The patient, a once-healthy 33-year-old, arrived at the hospital with Influenza B complicated by a secondary, severe infection of Pseudomonas aeruginosa, a bacterium that in this case proved resistant even to carbapenemsβ€”our antibiotics of last resort. This combination of infections triggered acute respiratory distress syndrome (ARDS), a condition where the lungs become so inflamed and fluid-filled that oxygen can no longer reach the blood.

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Β© Yuichiro Chino

Increased Scrutiny Leads to an Improved Organ Transplant System

23 January 2026 at 05:03
A crackdown on problems with fairness and safety is achieving results, including a big drop in the number of sick patients being passed over for transplants.

Β© Alyssa Schukar for The New York Times

A medical worker holding a recovered kidney.

Toby Kiers, World Champion of Mycorrhizal Fungus

14 January 2026 at 15:15
This year’s recipient of the Tyler Prize for Environmental Achievement talks about β€œpunk science,” microbial economics and thinking like a mycorrhizal fungus.

Β© Tomas Munita for The New York Times

90 Minutes to Give Baby Luna a New Heart

1 January 2026 at 10:39
After eight years of training, Dr. Maureen McKiernan made her debut as the lead surgeon on an infant heart transplant β€” an operation on the edge of what’s possible.

Β© Victor J. Blue for The New York Times

Before Luna’s heart transplant, Dr. Goldstone advised Dr. McKiernan to β€œplan the surgery out β€” every detail down to the suture,” she recalled.
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