Sometimes, downing an energy drink can feel like refueling your battery. But with too much, that jolt can turn into a catastrophic surge that fries the wiring and blows a fuse. That was the unfortunate and alarming case for a man in the UK several years ago, according to a case report this week in BMJ Case Reports.

The man, who was in his 50s and otherwise healthy, showed up at a hospital after the entire left side of his body abruptly went numb and he was left with clumsy, uncoordinated muscle movements (ataxia). His blood pressure was astonishingly high, at 254/150 mm Hg. For context, a normal reading is under 120/80, while anything over 180/120 is considered a hypertensive crisis, which is a medical emergency.

The man had suffered a mild stroke, and his extremely high blood pressure was an obvious factor. But why his blood pressure had reached stratospheric heights was far less obvious to his doctors, according to the retrospective case report written by Martha Coyle and Sunil Munshi of Nottingham University Hospital.

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The Centers for Disease Control and Prevention is in critical condition. This year, the premier public health agency had its funding brutally cut and staff gutted, its mission sabotaged, and its headquarters riddled with literal bullets. The over 500 rounds fired were meant for its scientists and public health experts, who endured only to be sidelined, ignored, and overruled by Health Secretary Robert F. Kennedy Jr., an anti-vaccine activist hellbent on warping the agency to fit his anti-science agenda.

Then, on August 27, Kennedy fired CDC Director Susan Monarez just weeks after she was confirmed by the Senate. She had refused to blindly approve vaccine recommendations from a panel of vaccine skeptics and contrarians that he had hand-selected. The agency descended into chaos, and Monarez wasn’t the only one to leave the agency that day.

Three top leaders had reached their breaking point and coordinated their resignations upon the dramatic ouster: Drs. Demetre Daskalakis, Debra Houry, and Daniel Jernigan walked out of the agency as their colleagues rallied around them.

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A single sperm donor who carries a rare cancer-causing genetic mutation has fathered at least 197 children across 14 countries in Europe, according to a collaborative investigation by 14 European news groups.

According to their investigative report, some of the children have already died, and many others are expected to develop deadly cancers.

The man—Donor 7069, alias “Kjeld”—carries a rare mutation in the TP53 gene, which codes for a critical tumor suppressor called protein 53 or p53. This protein (which is a transcription factor) keeps cells from dividing uncontrollably, can activate DNA repair processes amid damage, and can trigger cell death when a cell is beyond repair. Many cancers are linked to mutations in p53.

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Rep. Haley Stevens (D-Mich.) filed articles of impeachment against Health Secretary Robert F. Kennedy Jr. Wednesday, accusing him of abusing the powers of his office and undermining public health, putting Americans’ lives at risk.

He “has got to go,” Stevens said in a video announcing the impeachment articles. In an accompanying press statement, she said Kennedy, who rose to prominence as an ardent anti-vaccine activist, “has turned his back on science, on public health, and on the American people—spreading conspiracies and lies, driving up costs, and putting lives at risk.”  She called him the “biggest self-created threat to our health and safety.”

It is very unlikely that an impeachment push will gain traction in the Republican-controlled Congress. No other Democratic lawmakers are backing the articles.

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A measles outbreak that began in South Carolina at the start of October is showing no signs of slowing as officials on Tuesday reported 27 new cases since Friday. Those cases bring the outbreak total to 111.

The southern state’s outbreak now rivals outbreaks ongoing in Utah and Arizona, which have tallied 115 and 176 cases, respectively. The outbreaks are threatening to cost the country its measles elimination status, which was earned in 2000 after vaccination efforts stopped the virus from spreading continuously. If the current transmission of the virus isn’t halted by January, the virus will have circulated for 12 consecutive months, marking it once again as an endemic disease in the US.

In an update on Tuesday, South Carolina’s health department suggested the spread is far from over. Of the state’s 27 new cases, 16 were linked to exposure at a church, the Way of Truth Church in Inman. And amid the new cases, new exposures were identified at Inman Intermediate School. That’s on top of exposures announced Friday at four other schools in the region, which led to well over 100 students being quarantined.

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Federal vaccine advisors hand-selected by anti-vaccine Health Secretary Robert F. Kennedy Jr. have voted to eliminate a recommendation that all babies be vaccinated against hepatitis B on the day of birth. The decision was made with no evidence of harm from that dose and no evidence of any benefit from the delay.

Public health experts, medical experts, and even some members of the panel decried the vote, which studies and historical data indicate will lead to more infections in babies that, in turn, will lead to more cases of chronic liver disease, liver cancer, and premature death.

“I will just say we have heard ‘do no harm’ is a moral imperative. We are doing harm by changing this [recommendation],” Cody Meissner, a pediatrician and voting member of the Advisory Committee on Immunization Practices (ACIP), said as he voted against the change.

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The panel of federal vaccine advisors hand-selected by anti-vaccine Health Secretary Robert F. Kennedy Jr. has once again punted on whether to strip recommendations for hepatitis B vaccinations for newborns—a move it tried to make in September before realizing it didn’t know what it was doing. The decision to delay the vote today came abruptly this afternoon when the panel realized it still does not understand the topic or what it was voting on.

Prior to today’s 6–3 vote to delay a decision, there was a swirl of confusion over the wording of what a new recommendation would be. Panel members had gotten three different versions of the proposed recommendation in the 72 hours prior to the meeting, one panelist said. And the meeting’s data presentations this morning offered no clarity on the subject—they were delivered entirely by anti-vaccine activists who have no subject matter expertise and who made a dizzying amount of false and absurd claims.

“Completely inappropriate”

Overall, the meeting was disorganized and farcical. Kennedy’s panel has abandoned the evidence-based framework for setting vaccine policy in favor of airing unvetted presentations with misrepresentations, conspiracy theories, and cherry-picked studies. At times, there were tense exchanges, chaos, confusion, and misunderstandings.

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On Friday, Vinay Prasad—the Food and Drug Administration’s chief medical and scientific officer and its top vaccine regulator—emailed a stunning memo to staff that quickly leaked to the press. Without evidence, Prasad claimed COVID-19 vaccines have killed 10 children in the US, and, as such, he announced unilateral, sweeping changes to the way the agency regulates and approves vaccines, including seasonal flu shots.

On Wednesday evening, a dozen former FDA commissioners, who collectively oversaw the agency for more than 35 years, responded to the memo with a scathing rebuke. Uniting to publish their response in the New England Journal of Medicine, the former commissioners said they were “deeply concerned” by Prasad’s memo, which they framed as a “threat” to the FDA’s work and a danger to Americans’ health.

In his memo, Prasad called for abandoning the FDA’s current framework for updating seasonal flu shots and other vaccines, such as those for COVID-19. Those updates currently involve studies that measure well-characterized immune responses (called immunobridging studies). Prasad dismissed this approach as insufficient and, instead, plans to require expensive randomized trials, which can take months to years for each vaccine update.

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The top drug regulator at the Food and Drug Administration, Richard Pazdur, has decided to retire from the agency just three weeks after taking the leading position, according to multiple media outlets.

Pazdur, an oncologist who has worked at the FDA since 1999, was seen as a stabilizing force for an agency that has been mired in turmoil during the second Trump administration. He took over the role of leading the FDA’s Center for Drug Evaluation and Research on November 11, after the previous leader, George Tidmarsh, left the agency amid an investigation and a lawsuit regarding allegations that he used his position to exact petty revenge on a former business partner. In light of the scandal, one venture capital investor called the agency a “clown show.” Drug industry groups, meanwhile, called the FDA erratic and unpredictable.

Pazdur’s selection was seen as a positive sign by agency insiders, drug industry representatives, and patient advocacy groups, according to reporting by The Washington Post.

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When the federal vaccine committee hand-picked by anti-vaccine Health Secretary Robert F. Kennedy Jr. meets again this week, it will have yet another new chairperson to lead its ongoing work of dismantling the evidence-based vaccine recommendations set by the Centers for Disease Control and Prevention.

On Monday, the Department of Health and Human Services announced that the chairperson who has been in place since June—when Kennedy fired all 17 expert advisors on the committee and replaced them with questionably qualified allies—is moving to a senior role in the department. Biostatistician Martin Kulldorff will now be the chief science officer for the Office of the Assistant Secretary for Planning and Evaluation (ASPE), HHS said. As such, he’s stepping down from the vaccine committee, the Advisory Committee on Immunization Practices (ACIP).

Kulldorff gained prominence amid the COVID-19 pandemic, criticizing public health responses to the crisis, particularly lockdowns and COVID-19 vaccines. He was a co-author of the Great Barrington Declaration that advocated for letting the deadly virus spread unchecked through the population, which was called unethical by health experts.

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If you need some motivation to keep from eating too much this Thanksgiving, here it is: Doctors in Romania pulled an 11 cm (4.3 inch) living, writhing round worm from a woman’s left eyelid.

According to a report in the New England Journal of Medicine, the worm likely hatched from a hard lump in her right temple, which the woman recalled first spotting a month beforehand. She also noticed that the nodule had vanished just a day before the worm apparently made a squiggly run for her eye.

When she went to an ophthalmologist the next day, doctors immediately noted the “mobile lesion” on her eyelid, which was in the suspicious shape of a bunched-up worm just under her skin with a little redness and swelling.

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Under ardent anti-vaccine Health Secretary Robert F. Kennedy Jr., the Centers for Disease Control and Prevention has named Louisiana Surgeon General Ralph Abraham as its new principal deputy director—a choice that was immediately called “dangerous” and “irresponsible,” yet not as bad as it could have been, by experts.

Physician Jeremy Faust revealed the appointment in his newsletter Inside Medicine yesterday, which was subsequently confirmed by journalists. Faust noted that a CDC source told him, “I heard way worse names floated,” and although Abraham’s views are “probably pretty terrible,” he at least has had relevant experience running a public health system, unlike other current leaders of the agency.

But Abraham hasn’t exactly been running a health system the way most public health experts would recommend. Under Abraham’s leadership, the Louisiana health department waited months to inform residents about a deadly whooping cough (pertussis) outbreak. He also has a clear record of anti-vaccine views. Earlier this year, he told a Louisiana news outlet he doesn’t recommend COVID-19 vaccines because “I prefer natural immunity.” In February, he ordered the health department to stop promoting mass vaccinations, including flu shots, and barred staff from running seasonal vaccine campaigns.

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The popularity of GLP-1 weight-loss medications continues to soar—and their uptake is helping to push down obesity rates on a national scale—but a safe, evidence-based way off the drugs isn’t yet in clear view.

An analysis published this week in JAMA Internal Medicine found that most participants in a clinical trial who were assigned to stop taking tirzepatide (Zepbound from Eli Lilly) not only regained significant amounts of the weight they had lost on the drug, but they also saw their cardiovascular and metabolic improvements slip away. Their blood pressure went back up, as did their cholesterol, hemoglobin A_1c (used to assess glucose control levels), and fasting insulin.

In an accompanying editorial, two medical experts at the University of Pittsburgh, Elizabeth Oczypok and Timothy Anderson, suggest that this new class of drugs should be rebranded from “weight loss” drugs to “weight management” drugs, which people may need to take indefinitely.

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A man in Ireland earned the unpleasant distinction of developing an exceedingly rare infection on his penis—one that has a puzzling origin, but may be connected to his work with dead animals.

According to an article published in ASM Case Reports on Thursday, the 57-year-old man went to a hospital in Dublin after his penis became red, swollen, and painful over the course of a week. He also had a fever. Doctors promptly admitted him to the hospital and noted that he had received a kidney transplant 15 years prior. As such, he was on immunosuppressive drugs, which keep his body from rejecting the organ, but could also allow infections to run amok.

Initial blood work found hints of an infection, and the doctors initially suspected a bacterial skin infection (cellulitis) had taken hold in his nether region. So, they put him on some standard antibiotics for that. But his penis only got worse, redder, and more swollen. This prompted consultation with infectious disease doctors.

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ByHeart announced on Thursday that its own testing identified the bacterium that causes botulism in its baby formula, which is linked to an ongoing infant botulism outbreak that has doubled since last week.

As of November 19, there have been 31 cases across 15 states—up from 15 cases in 12 states reported last week. All 31 cases so far have been hospitalized. No deaths have been reported.

The outbreak was announced on November 8, and ByHeart was, at first, unusually aggressive in deflecting blame for linked illnesses.

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With ardent anti-vaccine activist Robert F. Kennedy Jr. as the country’s top health official, a federal webpage that previously laid out the ample evidence refuting the misinformation that vaccines cause autism was abruptly replaced Wednesday with an anti-vaccine screed that promotes the false link.

It’s a move that is sure to be celebrated by Kennedy’s fringe anti-vaccine followers, but will only sow more distrust, fear, and confusion among the public, further erode the country’s crumbling vaccination rates, and ultimately lead to more disease, suffering, and deaths from vaccine-preventable infections, particularly among children and the most vulnerable.

On the Centers for Disease Control and Prevention’s website titled “Autism and Vaccines,” the previous top “key point” accurately reported that: “Studies have shown that there is no link between receiving vaccines and developing autism spectrum disorder (ASD).”

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