Enlarge / The spliceosome is a large complex of proteins and RNAs. (credit: NCBI)

Almost 1,500 genes have been implicated in intellectual disabilities; yet for most people with such disabilities, genetic causes remain unknown. Perhaps this is in part because geneticists have been focusing on the wrong stretches of DNA when they go searching. To rectify this, Ernest Turro—a biostatistician who focuses on genetics, genomics, and molecular diagnostics—used whole genome sequencing data from the 100,000 Genomes Project to search for areas associated with intellectual disabilities.

His lab found a genetic association that is the most common one yet to be associated with neurodevelopmental abnormality. And the gene they identified doesn’t even make a protein.

Trouble with the spliceosome

Most genes include instructions for how to make proteins. That’s true. And yet human genes are not arranged linearly—or rather, they are arranged linearly, but not contiguously. A gene containing the instructions for which amino acids to string together to make a particular protein—hemoglobin, insulin, serotonin, albumin, estrogen, whatever protein you like—is modular. It contains part of the amino acid sequence, then it has a chunk of DNA that is largely irrelevant to that sequence, then a bit more of the protein’s sequence, then another chunk of random DNA, back and forth until the end of the protein. It’s as if each of these prose paragraphs were separated by a string of unrelated letters (but not a meaningful paragraph from a different article).

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Software product development initiatives are not an easy feat especially when 80% of the projects fail for one reason or another. Executing software development is...Read More

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An innovative programme in the Colombian capital is giving a new kind of support and confidence to caregivers, most of them women

Adela Rubiano Hurtado does not feel there was a point when she made the decision to care for her granddaughter. It was just that when Rubiano’s daughter became pregnant at 15, and could not care for the baby, there was no one else.

“I never considered it a job or a career,” the 67-year-old says from an armchair in her house overlooking the urban sprawl creeping up the mountains of Colombia’s capital, Bogotá. “Who else was going to do it?”

Increasingly frequent natural disasters leave islanders reliant on processed foods for months on end – with deeply concerning knock-on effects to health

When twin cyclones Judy and Kevin hammered their way through the 83 tropical islands of Vanuatu in March 2023, the government and NGOs were quick to distribute supplies. The South Pacific country’s crops had been decimated and the need to feed the 300,000-plus population was a priority.

The bags of rice, packets of noodles and tinned tuna that communities depend on for the months after a disaster were welcomed. But unlike native staples such as yams, taro and sweet potato, these emergency foods only serve to worsen the region’s non-communicable diseases (NCDs) problem, according to experts.

We are thrilled to announce that two of our exceptional team members, Joanne Guariglia and Kelly Hiscoe, have been recognized as CRN's 2024 Women of the Channel. This recognition celebrates the achievements and leadership of women within the channel community, and we are incredibly proud to see Joanne and Kelly honored for their contributions.

Kelly Hiscoe: Driving innovation in partner programs

Kelly Hiscoe and her team are at the forefront of designing and launching partner programs, optimizing our operations to support Rapid7's global channel ecosystem. Their commitment to creating highly effective and streamlined partner experiences ensures seamless execution within our channel. Engaging continuously with partners, Kelly's team drives simplified, scalable, and predictable experiences that benefit all stakeholders.

Kelly's dedication to improving our operational infrastructure and incentive programs is unwavering. Kelly said: "We will never be done focusing on creating improved programs and processes. We will continue to be laser focused on enhancing our operational infrastructure and incentive programs because we care deeply about the partner experience with Rapid7."

Her leadership and vision are integral to our ongoing success and the satisfaction of our partners.

Joanne Guariglia: Building lasting relationships

Joanne Guariglia has demonstrated exceptional skill in building and nurturing lasting relationships with our partners, an area in which Rapid7 are investing heavily -  making strides with the channel community more than ever.

"What I enjoy most is being able to build lasting relationships with our partners. Partners want to work with trusted brands who are leaders in the space, and we have that here at Rapid7. Being that trusted voice and growing the relationship, while educating them about our offerings, enables me to have a positive impact," Joanne said.

Her dedication to partner success and her ability to educate and inform are key components of her impactful work.

Commitment to excellence

At Rapid7, we are committed to fostering an environment where talented individuals like Joanne and Kelly can thrive. Their recognition as CRN's 2024 Women of the Channel underscores our dedication to excellence and our focus on building a strong, supportive channel ecosystem. We look forward to their continued contributions and to the ongoing success of our partners.

Please join us in celebrating Joanne and Kelly for their outstanding achievements and their unwavering commitment to excellence in the channel community.

Learn more about Rapid7 global partnerships here.

The viral disease kills 5,000 people a year in west Africa, and has been described as an epidemic threat to global health

Clinical trials for the first new treatment for Lassa fever in almost 40 years are planned to be held in Nigeria this year.

The neglected tropical disease kills about 5,000 people a year and is endemic in west Africa.

Letter urges US company Gilead Sciences to ‘shape history’ by providing fair access

Former world leaders, celebrities and a Nobel prize-winning scientist who helped discover HIV have written to a leading pharmaceutical company to urge it to make a “gamechanger” HIV medicine available to people living outside wealthy countries.

The US company Gilead Sciences has been urged to “shape history” by avoiding a repeat of the “horror and shame” of the early years of the Aids pandemic, when 12 million lives were lost in poorer parts of the world after effective drugs became available, because the medicines were not affordable.

Health leaders say extensive negotiations still needed to agree set of measures on how the world should prevent and respond to future pandemics

• Explainer: What is the pandemic accord and why have negotiations been so difficult?

Global health leaders have said an international treaty governing how the world should deal with future pandemics may not be agreed for another year or more.

After two years of negotiations, countries failed to agree on the text of an international pandemic accord by a deadline of 24 May. And at the World Health Assembly in Geneva on Tuesday delegates said extensive further negotiations would be needed.

Study confirms huge concentrations of potentially dangerous PFAS in rivers, lakes and taps in Dhaka

Rivers, lakes and tap water in areas of Bangladesh that host garment factories are swarming with dangerous levels of toxic “forever chemicals”, some with links to serious health issues, according to new research.

In the first study of its kind conducted in Bangladesh, a global fashion hub supplying international brands, per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, were found in 27 water samples collected close to textile factories in the capital, Dhaka.

With the country’s highest rates of unemployment, the Nelson Mandela Bay municipality in Eastern Cape province offers a snapshot of the state of South Africa’s housing, employment, poverty, crime, and public service delivery. As the country goes to the polls, many of those voting will be part of the ‘born free’ generation who were born after apartheid ended in 1994. On a visit to Nelson Mandela Bay in December, the photojournalist Ilvy Njiokiktjien spoke to many about their disillusionment with modern South Africa but also their hopes, ingenuity and resilience

Exclusive: Johnston Busingye formally appointed days after UK agreed Rwanda asylum deal with Paul Kagame in 2022

Rwanda’s top diplomat in the UK oversaw the use of the international justice system to target opponents of the country’s rulers around the world, the Guardian can reveal.

New details of the Rwandan government’s suppression of opposition beyond its borders add to concerns about the regime at the heart of Rishi Sunak’s asylum policy.

The Mexican capital’s Unesco-listed wetlands are being brought back to life by the Indigenous chinamperos, who are striving to overcome the effects of urbanisation and the climate crisis

British doctors Mohammed Tahir and Omar El-Taji thought they were mentally prepared to help treat people in Rafah. But what they and other foreign volunteers faced was beyond anything they could have imagined

Just a few days after arriving at a hospital outside Rafah in the Gaza Strip, Dr Omar El-Taji – a urologist who usually works in Manchester – was woken up at 2am to operate on an urgent case. “A man in his 30s was brought in after his entire building was bombed,” he says. “He had an open wound to his abdomen, his hand was falling off, and his ankles were completely mangled.”

The man was quickly taken into the operating room. “The shrapnel had completely sliced through him – I had never seen anything like it,” says El-Taji.

An arts centre in the Ugandan capital, Kampala, has given some of Sudan’s best known creatives a chance to work in peace – and find inspiration again

Among the paintings that Nusreldin Eldouma left behind when he fled Sudan is a watercolour portrait showing a Sufi sage, a popular figure from Sudanese folklore. Painted last year – just before Sudan was dragged into war after a power struggle between two factions of the country’s military – it shows the 17th-century sheikh Farah wad Taktook, an icon of peace, says Eldouma. Now he only has photographs to show, the canvases that are his life’s work left behind in the ruins of the city of Khartoum.

Photographs of Nusreldin Eldouma’s work displayed at 32° East (above) and his watercolour of a Sufi man, entitled Inner Peace (below; image courtesy of the artist)

Vulnerable economies must be supported with finance and practical aid to find long term solutions, says Jorge Moreira da Silva of Unops

The world has a “moral responsibility” to support the fight for survival being faced by small island states, according to a leading UN agency chief.

Ahead of the fourth annual conference of small island developing states (Sids) being held in Antigua and Barbuda this week, Jorge Moreira da Silva, the executive director of the (Unops), called for recognition of the problems faced by what he called “some of the most vulnerable economies in the world” who contributed less than 1% to global carbon emissions.

One of the most critical yet often overlooked aspects of cybersecurity is the timely patching of vulnerabilities. While much attention is given to sophisticated phishing attacks and the menace of password brute-forcing, the importance of addressing unpatched vulnerabilities cannot be overstated. These vulnerabilities represent low-hanging fruit for cybercriminals, offering a relatively straightforward path into systems. […]

The post The Importance of Patching Vulnerabilities in Cybersecurity appeared first on TuxCare.

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The hopes raised by the ANC coming to power in 1994 have, 30 years on, been dashed for millions still without a decent roof over their heads

A picture of Nelson Mandela watches over the dimly lit room where Maggie Mothemba has lived for six years. “He’s like my father,” says the 57-year-old, who remembers the day in April 1994 that she voted for Mandela’s African National Congress in South Africa’s first democratic election.

She was then “full of hope” to be on the list for a government-subsidised house to raise her two children – a key ANC’ election promise. But Mothemba is still waiting, along with 2.5 million households languishing in a housing crisis. In 2017, facing eviction from a private rental , she moved into a derelict hospital in Woodstock, a Cape Town neighbourhood, squatted by people protesting the slow pace of affordable housing development.

As demand for sustainable housing grows, architects go back to basics to future-proof homes for a changing climate

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“Energy efficient”, “carbon neutral” and “net zero” are buzzwords we hear more and more as we face the impact of climate change. But do we think about them enough in building?

Globally, a move towards sustainable housing is growing. In Europe, efforts to move to greener homes hope to combat rising energy costs and be better for the planet. But 40% of global carbon dioxide emissions still come from the real estate sector.

Thirty years after the end of apartheid, corruption is rife, crime is high and the economy is a mess. The party of Mandela admits it ‘made mistakes’. But will the people forgive them?

In the heart of Soweto, the birthplace of South African democracy has been burned, looted and stripped for parts.

Almost 70 years ago, in the early days of apartheid, more than 3,000 people gathered in a dusty square to draw up the Freedom Charter, demanding a series of rights and proclaiming that South Africa “belongs to all who live in it, black and white”.

Concerns grow that Darfur is facing another genocide as Rapid Support Forces besiege city of El Fasher

Tens of thousands of people have fled their homes in a displacement camp in the city of El Fasher in Sudan’s Darfur region after attacks by the Rapid Support Forces paramilitary group, as concern grows that Darfur is facing another genocide.

The RSF has besieged the city for weeks, aiming to take the last major population centre in Darfur that it does not control. Hundreds of thousands are sheltering there after fleeing other cities taken by the group over the past year.

Gustavo Gorriti, who has long exposed corruption, is the target of a criminal investigation campaigners call ‘politically motivated’

For more than four decades, Gustavo Gorriti has been a thorn in the side of corrupt elites, relentlessly uncovering government wrongdoing in Latin America – most recently exposing an unprecedented level of graft in Operation Car Wash, the continent-wide scandal that has ensnared nearly every elected Peruvian president of this century.

Gorriti made his name reporting the bloody rise of the Mao-inspired Shining Path. He was kidnapped by military intelligence agents during Alberto Fujimori’s 1992 power grab after unmasking his shadowy spymaster Vladimiro Montesinos.

In the state of Rio Grande do Sul, authorities are struggling to find shelter for half a million displaced people as a health crisis looms

As the rain poured down during the night of 3 May, a stream of people began to arrive at the Lutheran University of Brazil in Canoas, a city in the southernmost state of Brazil, Rio Grande do Sul. For a week, heavy rains had been pummelling the landscape, raising river levels and flooding homes, forcing many to seek shelter elsewhere.

Three weeks later, the university harbours thousands of people and is the largest camp for the displaced amid a growing humanitarian crisis in the state of 10 million inhabitants. More than 580,000 people have been displaced, with almost 70,000 of them depending on shelters, according to a state government report. A total of 2.3 million people have been affected by the torrential rain and floods.

Finally, a report has listed the long-term health complications for women worldwide – and the NHS should take note

Birth is usually a time of celebration, when we recognise the miracle of life as a child is brought into the world. In Britain, childbirth used to be a much more fraught experience, with a high risk of death for mother and baby. But scientific progress and modern medicine have reduced infant deaths for every 1,000 live births from 31.7 in 1950 to just four by 2020. Deaths are relatively higher than Finland’s and Japan’s infant mortality rates, of about two for every 1,000, but much lower than Afghanistan at 103.1.

Once a woman and her baby survive childbirth, several weeks of follow-up is routine in many countries to ensure that any urgent health issues are resolved. This six- to eight-week period is called postnatal care, as women recover from their labour and delivery, especially if they’ve had a C-section or episiotomy. But what happens to new mothers after that handful of weeks? They usually disappear from the health system and are left on their own to cope with recovery.

Prof Devi Sridhar is chair of global public health at the University of Edinburgh

Fasiha Hassan is the same age as her country’s democracy and as election day approaches, the politician believes her party, the ANC, must evolve or die

They are called the “born-free” South Africans – too young to remember apartheid and with no instinctive loyalty to the African National Congress. And they could deliver a stinging rebuke to the party that led the liberation struggle, if this generation votes at all in elections on 29 May.

Three decades on from the birth of democracy in the country, the ANC could see its vote share fall below 50% for the first time.

Kidney disease is on the rise in coastal communities, where some have no choice but to drink and cook with contaminated water

Shadows dance across large, concrete chambers while the sound of dripping water echoes in the distance. A rusty metal staircase leads up to an empty water tower overlooking Bangladesh’s mighty Rupsha River. This water treatment plant was once a beacon of hope for the community; today the site lies abandoned, the only sign of life the daily activity of its resident caretaker, Sayed Ahmed.

Commissioned by the local government division for rural development to recycle contaminated water, the plant on the outskirts of the city of Khulna was designed to supply fresh water to 5,000 people. When construction began in 2005, Ahmed was offered employment as a security guard.

The accord – conceived during Covid to prevent and respond to pandemics – will top the agenda at the World Health Assembly

Global health leaders will gather in Geneva on 27 May at the annual World Health Assembly, where a new agreement for countries to work together to prepare for, prevent, and respond to pandemics – known as the “pandemic accord” – will top the agenda.

It was first proposed by world leaders in early 2021, with a promise to avoid the mistakes of the Covid-19 pandemic next time around.

After old rivalries between Dogon farmers and Fulani herders erupted into violence, exacerbated by Islamist rebels, thousands of the semi-nomadic pastoralists have fled to camps in towns, leaving their cherished animals and way of life. Many must beg to survive at sites lacking food and clean water, with no end in sight to the conflict

Conservationists say Barbara Creecy has failed to implement vital changes to stop fishing around colonies amid fears African penguins could be extinct by 2035

It’s 3.40pm on a Thursday and Penguin 999.000000007425712 has just returned to the Stony Point penguin colony in Betty’s Bay, South Africa, after a day of foraging. She glides elegantly through the turquoise waters before clambering comically up the rocks towards the nest where her partner is incubating two beige eggs. She doesn’t realise it, but a rudimentary knee-high fence has funnelled her towards a state-of-the-art weighbridge. When she left the colony at 6.45am this morning she weighed 2.7kg. Now, after a full day of hunting, she has gained only 285g.

Eleanor Weideman, a coastal seabird project manager for BirdLife South Africa, is concerned. “In a good year they come back with their stomachs bulging,” she says. Penguins can put on up to one-third of their body weight in a single day of foraging. “But there’s just no fish out there any more.”

Joe Biden and Donald Trump agree on tariffs against China. The world has lost its biggest cheerleader for globalisation

The biggest shift in American politics has nothing to do with Stormy Daniels or Michael Cohen, Fox News or golf courses. Indeed, its author is not Donald J Trump. Yet the implications stretch far beyond this year’s presidential elections, and affect countries across the world. The era of free trade is dying, and the man bringing down the guillotine represents the party that in the past three decades has been evangelically pro-globalisation: the Democrats.

Last week, Joe Biden imposed tariffs on a range of Chinese-made goods. Electric cars produced in China will now be hit with import tax of 100%, chips and solar cells 50% and lithium-ion batteries 25%. These and other tariffs on goods worth an estimated $18bn a year amount to a rounding error in the giant US economy. And in an election year, Mr Biden, who hails from Scranton, Pennsylvania, is fretting about support not only in his home state but across the country’s industrial heartland, gutted by decades of free trade.

Do you have an opinion on the issues raised in this article? If you would like to submit a response of up to 300 words by email to be considered for publication in our letters section, please click here.

With heatwaves becoming more frequent in Bengaluru and other cities across the country, climate planning must look to people on the margins, experts say

Venkatachala starts his day early, neatly arranging jasmine, roses, chrysanthemums and crossandras on his pushcart. He then heads out on to the streets of Bengaluru, calling out to customers who use fresh flowers for religious rituals and daily prayers at home.

His goal this summer has been to sell most of his stock before 10am. Venkatachala knows that with each hour after that, his flowers will wilt, and the odds of selling them and the income he can expect will fall significantly.

More than 2,500 attacks in 2023, including medics killed and clinics bombed, in war zones such as Gaza, Sudan and Ukraine

Attacks on health workers, hospitals and clinics in conflict zones jumped 25% last year to their highest level on record, a new report has found.

While the increase was largely driven by new wars in Gaza and Sudan, continuing conflicts such as Ukraine and Myanmar also saw such attacks continue “at a relentless pace”, the Safeguarding Health in Conflict coalition said.

Sharp rise in number of people facing a crisis in freedom of speech, while authors particularly alarmed by deterioration in India under Narendra Modi

Half the world’s population cannot freely speak their mind according to a new report on freedom of expression.

In its annual report, the advocate group Article 19 found the number of people facing a “crisis” in freedom of speech and information was the highest this century after a sharp rise from 34% in 2022 to 53% in 2023.

Communities around the Pueblo Viejo mine complain of serious health problems and a diminished environment and have spent years campaigning to be relocated

In the shadow of El Llagal, a tailings dam that holds waste from one of the world’s largest goldmines in the Dominican Republic, sits the home of Casilda Lima. The roof is corrugated iron and the walls are wood, painted pink and yellow. A sign reads “God bless this home”.

Outside,the 114-metre-tall grey wall of the dam looms large. Behind it lies a lake of waste from the mining process, where machinery and chemicals, along with a huge volume of water, are used to grind up rock to extract gold and silver. Many substances found in tailings are lethal, others are radioactive.

As the conflict in Gaza continues, reconciliation may seem a distant dream, but on both sides there are those working for peace

On the morning of 7 October, as news emerged of the Hamas attack on Israeli communities near the Gaza border, Naama Barak Wolfman joined thousands of others frantically texting their friends and family. “Checking you’re alright,” she wrote to her colleague, Vivian Silver, a Canadian who spent decades working to foster peace between Israelis and Palestinians.

The text was never read. Silver was one of several peace activists killed that day, though news of her murder took nearly a month to reach Silver’s friends and family. Many believed the Women Wage Peace leader had been taken hostage, even picturing her negotiating with her captors.

Experts call for conservation action as the features on Rapa Nui’s famous monoliths are eroded by fire and rain

The Ahu Tahai moai, on the east side of Rapa Nui, also known as Easter Island, is an impressive 4.5 metres high. Carved from a soft volcanic rock, the statue looks out solemnly over the island, with its back to the bay.

The Tahai (“where the sun sets”) and the island’s other thousand or so moai were erected roughly between 1100 and 1700 as a representation of Rapa Nui’s ancestors.

AntennaPod has been around for a long time – the first bit of code was published in 2011. Since then, the app has grown massively and had several main developers. The beauty of open-source is that so many people can contribute and make a great app together. But sometimes having many people work on a project can lead to different ways of thinking about how to structure the project. Because of this, AntennaPod gradually grew to have a number of weird code constructs. Our latest release, version 3.4, fixes this.

↫ ByteHamster

The AntennaPod team had an incredible task ahead of itself, and while it took them a few years, they pulled it off. The code structure graphs from before and after the code restructuring illustrate better than words ever could what they achieved. Thy changed 10000 lines of source code in 62 pull requests for this restructuring alone, while still adding new major features in the meantime. Pretty incredible.

In recent developments concerning WordPress security, a significant vulnerability has come to light in the widely used LiteSpeed Cache plugin. This LiteSpeed cache bug, labeled CVE-2023-40000, poses a substantial risk to WordPress site owners, as it allows threat actors to exploit websites, gaining unauthorized access and control. Let’s delve into the details of this vulnerability, […]

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Iran’s supreme leader has announced a five-day mourning period, but there have been fireworks and cheering in the country since the death was confirmed

Activists in Iran have said there is little mood to mourn the death of the country’s president, Ebrahim Raisi, who was killed in a helicopter crash near the border with Azerbaijan on Sunday.

Iran’s supreme leader, Ayatollah Khamenei, announced a five-day public mourning period after the deaths of Raisi, the foreign minister Hossein Amir-Abdollahian and other passengers on the helicopter. However, Iranians who spoke to the Guardian have refused to lament the death of a man who they say was responsible for hundreds of deaths in his four-decade political career.

It was during Raisi’s tenure that protests swept the country after the death of the 22-year-old Kurdish woman Mahsa Amini, who died in police custody after being arrested by police under Iran’s harsh hijab laws. More than 19,000 protesters were jailed, and at least 500 were killed – including 60 children – during the Woman, Life, Freedom protests. The police continue to violently arrest women for refusing hijab rules.

The trailblazing musician was a powerful force for change and unity, and his legacy continues to inspire millions. He deserves his homeland’s highest honour

He is a 20th-century global icon but not officially designated a national hero in his own land. In a recent interview at the Bob Marley: One Love movie premiere, Jamaica’s prime minister, Andrew Holness, disclosed that his government was considering again the longstanding petitions to award its highest honour to the legend. Marley’s profound impact on music and Jamaican culture is undeniable. From Kingston to Harare, he stood for social justice and freedom and against colonialism. To have decades of deliberation by politicians on whether to declare him a national hero is baffling.

From baby boomers to generation X, growing up in the Caribbean was enriched by a vibrant and resonant tapestry of diverse music. The formative backdrop was artists such as Sam Cooke, Sparrow, Jim Reeves, Stevie Wonder, Earth Wind and Fire and Bob Marley. All could be heard back to back on the airwaves. Reggae was growing internationally, with Marley paving the way for the multitude of Caribbean artists to come.

San Pedro Sula is rated ‘dangerous’ as effects of forest fires, El Niño and the climate crisis cause a spike in respiratory illnesses

The air quality in San Pedro Sula, the second-largest city in Honduras, as been classified as the most polluted on the American continent due to forest fires and weather conditions aggravated by El Niño and the climate crisis.

IQAir, a Swiss air-quality organisation that draws data from more than 30,000 monitoring stations around the world, said on Thursday that air quality in the city of about 1 million people has reached “dangerous” levels.

Fossil-fuel dependent country hopes to provide bridge between wealthy global north and poor south at November gathering

Oil is inescapable in Baku, the capital of Azerbaijan. The smell of it greets the visitor on arrival and from the shores of the Caspian Sea on which the city is built the tankers are eternally visible. Flares from refineries near the centre light up the night sky, and you do not have to travel far to see fields of “nodding donkeys”, small piston pump oil wells about 6 metres (20ft) tall, that look almost festive in their bright red and green livery.

It will be an interesting setting for the gathering of the 29th UN climate conference of the parties, which will take place at the Olympic Stadium in November.

Yuxuan Shui, the developer behind the X11 compositor picom (a fork of Compton) published a blog post detailing their experiences with using GitHub Copilot for a year.

I had free access to GitHub Copilot for about a year, I used it, got used to it, and slowly started to take it for granted, until one day it was taken away. I had to re-adapt to a life without Copilot, but it also gave me a chance to look back at how I used Copilot, and reflect – had Copilot actually been helpful to me?

Copilot definitely feels a little bit magical when it works. It’s like it plucked code straight from my brain and put it on the screen for me to accept. Without it, I find myself getting grumpy a lot more often when I need to write boilerplate code – “Ugh, Copilot would have done it for me!”, and now I have to type it all out myself. That being said, the answer to my question above is a very definite “no, I am more productive without it”. Let me explain.

↫ Yuxuan Shui

The two main reasons why Shui eventually realised Copilot was slowing them down were its unpredictability, and its slowness. It’s very difficult to understand when, exactly, Copilot will get things right, which is not a great thing to have to deal with when you’re writing code. They also found Copilot incredibly slow, with its suggestions often taking 2-3 seconds or longer to appear – much slower than the suggestions from the clangd language server they use.

Of course, everybody’s situation will be different, and I have a suspicion that if you’re writing code in incredibly popular languages, say, Python or JavaScript, you’re going to get more accurate and possibly faster suggestions from Copilot. As Shui notes, it probably also doesn’t help that they’re writing an independent X11 compositor, something very few people are doing, meaning Copilot hasn’t been trained on it, which in turn means the tool probably has no clue what’s going on when Shui is writing their code.

As an aside, my opinion on GitHub Copilot is clear – it’s quite possibly the largest case of copyright infringement in human history, and in its current incarnation it should not be allowed to continue to operate. As I wrote over a year ago:

If Microsoft or whoever else wants to train a coding “AI” or whatever, they should either be using code they own the copyright to, get explicit permission from the rightsholders for “AI” training use (difficult for code from larger projects), or properly comply with the terms of the licenses and automatically add the terms and copyright notices during autocomplete and/or properly apply copyleft to the newly generated code. Anything else is a massive copyright violation and a direct assault on open source.

Let me put it this way – the code to various versions of Windows has leaked numerous times. What if we train an “AI” on that leaked code and let everyone use it? Do you honestly think Microsoft would not sue you into the stone age?

↫ Thom Holwerda

It’s curious that as far as I know, Copilot has not been trained on Microsoft’s own closed-source code, say, to Windows or Office, while at the same time the company claims Copilot is not copyright infringement or a massive open source license violation machine. If what Copilot does is truly fair use, as Microsoft claims, why won’t Microsoft use its own closed-source code for training?

We all know the answer.

Deeply questionable legality aside, do any of you use Copilot? Has it had any material impact on your programming work? Is its use allowed by your employer, or do you only use it for personal projects at home?

The effort aims to help close gender and racial pay gaps

Rapid7 is proud to announce their signing of the 100% Talent Compact through the Boston Women’s Workforce Council (BWWC). The Talent Compact is a collective effort among the Boston Mayor and local employers to close the gender and racial wage gaps in Greater Boston. Compact Signers are actively committed to examining their salary data, contributing that data anonymously to the BWWC’s biennial wage-gap measurement, and participating in quarterly briefing sessions.

As an organization, the BWWC works alongside the City of Boston’s Mayor as well as local employers. Their programs and initiatives reflect their core beliefs surrounding the positive impact women have on businesses and communities, the importance of addressing gender and racial pay inequities, and the systemic impact gender and racial pay disparities can have in Greater Boston.

As stated by Christina Luconi, Chief People Officer, “At Rapid7, we are committed to fostering an environment where all of our people are doing impactful work in a way that is meaningful to them. Ensuring that we have equitable salary practices is just one way we can ensure everyone has the opportunity to thrive in their career.”

In the United States, women earn 84 cents for every dollar earned by a man. In Boston, data collected by participants of the Talent Compact shows consistency with this number, with a wage gap of $0.21 for women and a gap of $0.27 for employees of color.

According to Lauren Noonan, Engagement Manager with the BWWC, “These numbers are disappointing to see, but measuring this data and understanding the work that needs to be done is the first critical step to creating necessary change. The companies that have signed on to our Talent Compact are committed to taking active roles in identifying gaps within their own organizations and actively participating in the panel discussions, sharing ideas, and putting corrective plans into action to address them.”

When it comes to diversity, equity and inclusion (DEI), Rapid7 has consistently demonstrated a commitment to focus efforts on driving impact; whether it’s through similar strategic partnerships with organizations like Hack.Diversity, Cyversity, and the University of South Florida or developing in-house resources and programs. Addressing systemic hurdles and supporting historically marginalized communities have become an integral part of our business strategy.

In addition to having programs and partnerships in place, Rapid7’s Director of Diversity, Equity and Inclusion, Sophia Dozier stresses how transparency is critical for creating impact and success. “Transparency is a key pillar in fostering spaces that are not only diverse and inclusive, but truly equitable. Levers of transparency should be embedded into every DEI strategy, as it helps ensure that decisions continue to reflect commitments made in support of building and maintaining impactful, high-performing, multi-dimensional teams and organizations.”

At Rapid7, we believe we are truly #NeverDone in our efforts to build an inclusive and equitable workplace where our employees can develop the career experience of a lifetime. This partnership furthers our commitment to continuously examining and enhancing our practices and programs so that all people can thrive, while being part of a greater discussion that impacts our industry and local community.

Jolie crystallises the programming concepts of service-oriented computing as linguistic constructs. The basic building blocks of software are not objects or functions, but rather services that can be relocated and replicated as needed. A composition of services is a service.

↫ Jolie website

Jolie is open source and available on GitHub.

GCC 14.1 has been released, and it should come as no surprise that the new features are not exactly something I, someone who doesn’t program, can properly parse. So, here’s the three items GCC itself thought were important to list first.

The C frontend when targeting standards newer than C89 now considers many non-standard constructs as errors that were previously only warnings. See https://gcc.gnu.org/gcc-14/porting_to.html#warnings-as-errors for more details. C23 _BitInt Bit-precise integer types are now supported, for now only on IA-32, x86-64 and AArch64.

The C++ frontend now implements several C++26 features, some missing C++23 bits and defect report resolutions. Diagnostics involving C++ templates now quote source from the instantiation context.

The libstdc++exp.a library now includes all symbols for the Filesystem TS and the experimental symbols for the C++23 std::stacktrace class, so -lstdc++exp can be used instead of -lstdc++fs. The libstdc++_libbacktrace.a library is not longer installed. Improved experimental support for C++20, C++23, and C++26. Updated parallel algorithms that are compatible with oneTBB.

↫ GCC 14.1 release announcement

GCC 14.1 is available for download, of course, but most of us will get it once it hits our distribution’s package repositories.

What is OWASP MASVS?

In case you didn't notice, the OWASP Mobile Top 10 List was just updated, for the first time since 2016! This is important for developers since this list represents the list of the most crucial mobile application security risks in 2024. This blog explains how this fits in with other OWASP security guidelines, summarizes each of the 10 risks and discusses some possible next steps for developers. 

The post 2024 OWASP Mobile Top Ten Risks appeared first on Security Boulevard.

We’re all aware of Stack Overflow – it’s a place where programmers and regular users can ask technical questions, and get answers from anyone who thinks they know the answer. Stack Overflow has become so ubiquitous among programmers and developers, the concept of “I just copied the code off Stack Overflow” has become a consistent meme to indicate you don’t fully grasp how something works, but at least it works.

If you’ve ever contributed answers to Stack Overflow, you might want to consider deleting them, altering them, or perhaps even go as far as request a GDPR removal if you’re in the European Union, because Stack Overflow has just announced a close partnership with “AI” company OpenAI (or, more accurately, “Open” “AI”). Stripped of marketing speak, the gist is exactly as you’d expect: OpenAI will absorb the questions and answers on Stack Overflow into its models, whether their respective authors like it or not.

As much as you may want to try and delete your answers if you’re not interesting in having your work generate profit for OpenAI, deleting popular questions and answers is not possible on Stack Overflow. The other option is altering your answers to render them useless, but it seems Stack Overflow is not going to allow you to do this, either. Ben Humphreys tried to alter his highest-rated answers, and Stack Overflow just reverted them back, and proceeded to ban him from the platform.

Stack Overflow does not let you delete questions that have accepted answers and many upvotes because it would remove knowledge from the community.

So instead I changed my highest-rated answers to a protest message.

Within an hour mods had changed the questions back and suspended my account for 7 days.

↫ Ben Humphreys

Now that they’ve made what is most likely an incredibly lucrative deal with OpenAI that’s going to net Stack Overflow’s owners boatloads of money, they obviously can’t let users delete or alter their answers to lower the monetary value of Stack Overflow’s content. Measures to prevent deletion or alteration are probably one of the clauses in the agreement between Stack Overflow and OpenAI. So there’s likely not much you can do to not have your answers sucked into OpenAI, but you should at least be aware it’s happening in case of future answers you might want to contribute.

Sixty years ago, on May 1, 1964, at 4 am in the morning, a quiet revolution in computing began at Dartmouth College. That’s when mathematicians John G. Kemeny and Thomas E. Kurtz successfully ran the first program written in their newly developed BASIC (Beginner’s All-Purpose Symbolic Instruction Code) programming language on the college’s General Electric GE-225 mainframe.

Little did they know that their creation would go on to democratize computing and inspire generations of programmers over the next six decades.

↫ Benj Edwards at Ars Technica

Even I have used BASIC in the past, when I was a child and discovered QBasic (or possibly GW-BASIC, I’m a bit hazy on the details) and started messing around with it. My experiences with BASIC didn’t lead to a path of ever more complex programming languages, but for huge numbers of people, it did – it’s wild just how many people over a certain age got their programming start with BASIC in the 8 bit home computer era.

I mean, 30 GOTO 10 is such a widespread morsel of knowledge it made its way into all kinds of popular media, such as a few Easter egg jokes in Futurama. BASIC has effectively achieved immortality.