Enlarge/ The Colorado River toad, also known as the Sonoran Desert Toad. (credit: Mark Newman)
It is becoming increasingly accepted that classic psychedelics like LSD, psilocybin, ayahuasca, and mescaline can act as antidepressants and anti-anxiety treatments in addition to causing hallucinations. They act by binding to a serotonin receptor. But there are 14 known types of serotonin receptors, and most of the research into these compounds has focused on only one of them—the one these molecules like, called 5-HT2A. (5-HT, short for 5-hydroxytryptamine, is the chemical name for serotonin.)
The Colorado River toad (Incilius alvarius), also known as the Sonoran Desert toad, secretes a psychedelic compound that likes to bind to a different serotonin receptor subtype called 5-HT1A. And that difference may be the key to developing an entirely distinct class of antidepressants.
Uncovering novel biology
Like other psychedelics, the one the toad produces decreases depression and anxiety and induces meaningful and spiritually significant experiences. It has been used clinically to treat vets with post-traumatic stress disorder and is being developed as a treatment for other neurological disorders and drug abuse. 5-HT1A is a validated therapeutic target, as approved drugs, including the antidepressant Viibryd and the anti-anxiety med Buspar, bind to it. But little is known about how psychedelics engage with this receptor and which effects it mediates, so Daniel Wacker’s lab decided to look into it.
Enlarge/ Elon Musk, in Paris, France, on Friday, June 16, 2023. Musk predicted his Neuralink Corp. would carry out its first brain implant later that year. The first implantation took place in January 2024. (credit: Getty | Nathan Laine)
The first invasive brain chip that Neuralink embedded into a human brain has malfunctioned, with neuron-surveilling threads appearing to have become dislodged from the participant's brain, the company revealed in a blog post Wednesday.
It's unclear what caused the threads to become "retracted" from the brain, how many have retracted, or if the displaced threads pose a safety risk. Neuralink, the brain-computer interface startup run by controversial billionaire Elon Musk, did not immediately respond to a request for comment from Ars. The company said in its blog post that the problem began in late February, but it has since been able to compensate for the lost data to some extent by modifying its algorithm.
Neuralink touts that its invasive implant includes 64 flexible threads carrying a total of 1,024 electrodes that can detect neuronal activity. Those flexible threads—described as thinner than a human hair—are inserted individually into the brain by the company's proprietary surgical robot. The goal is for the threads to be placed near neurons of interest so that signals detected by the electrodes can be recorded and decoded into intended actions, such as moving a cursor on a computer screen.
Ethan Zuckerman wants to release a tool that would allow Facebook users to control what appears in their newsfeeds. His privacy-friendly browser extension, Unfollow Everything 2.0, is designed to essentially give users a switch to turn the newsfeed on and off whenever they want, providing a way to eliminate or curate the feed.
Ethan Zuckerman, a professor at University of Massachusetts Amherst, is suing Meta to release a tool allowing Facebook users to "unfollow everything." (Photo by Lorrie LeJeune)
The tool is nearly ready to be released, Zuckerman told Ars, but the University of Massachusetts Amherst associate professor is afraid that Facebook owner Meta might threaten legal action if he goes ahead. And his fears appear well-founded. In 2021, Meta sent a cease-and-desist letter to the creator of the original Unfollow Everything, Louis Barclay, leading that developer to shut down his tool after thousands of Facebook users had eagerly downloaded it.
Zuckerman is suing Meta, asking a US district court in California to invalidate Meta's past arguments against developers like Barclay and rule that Meta would have no grounds to sue if he released his tool.
Amazon Prime Video subscribers will see new types of advertisements this broadcast year. Amazon announced today that it's adding new ad formats to its video streaming service, hoping to encourage people to interact with the ads and shop on Amazon.
In January, Prime Video streams included commercials unless subscribers paid $3 extra per month. That has meant that watching stuff on Prime Video ad-free costs $12 per month or, if you're also a Prime subscriber, $18 per month.
New types of Prime Video ads
Amazon has heightened focus on streaming ads this year. Those who opted for Prime Video with commercials will soon see shoppable carousel ads, interactive pause ads, and interactive brand trivia ads, as Amazon calls them. Amazon said that advertisers could buy these new displays to be shown "across the vast majority of content on Prime Video, wherever it’s streamed." All the new ad formats allow a viewer to place advertised products in their Amazon cart.
4min read Our identity federation capability better secures and streamlines CI/CD workflows, like in GitHub Actions and GitLab, with short-lived, secretless credentials.
Apple's newest iPad Pro puts an M4 chip inside a thinner frame and is available in new 11-inch and 13-inch sizes, while also upgrading the screens on both to "tandem" OLED displays for more brightness.
Compared to the last iPad Pro, released in early 2022, Apple is highlighting how thin and light these new Pros are. The 11-inch model is 5.3 mm thick and weighs less than a pound, while the 13-inch is 5.1 mm, which Apple says is its thinnest product ever, at 1.28 pounds.
The tandem OLED design, dubbed Ultra Retina XDR, delivers 1000 nits at full-screen brightness, and 1600 nits at peak HDR, equivalent to a high-end Samsung TV. The screens are "nano-texture glass," which is essentially a matte display finish.
Enlarge/ Kenneth Dintzer, litigator for the US Department of Justice, exits federal court in Washington, DC, on September 20, 2023, during the antitrust trial to determine if Alphabet Inc.'s Google maintains a monopoly in the online search business. (credit: Bloomberg / Contributor | Bloomberg)
Near the end of the second day of closing arguments in the Google monopoly trial, US district judge Amit Mehta weighed whether sanctions were warranted over what the US Department of Justice described as Google's "routine, regular, and normal destruction" of evidence.
Google was accused of enacting a policy instructing employees to turn chat history off by default when discussing sensitive topics, including Google's revenue-sharing and mobile application distribution agreements. These agreements, the DOJ and state attorneys general argued, work to maintain Google's monopoly over search.
According to the DOJ, Google destroyed potentially hundreds of thousands of chat sessions not just during their investigation but also during litigation. Google only stopped the practice after the DOJ discovered the policy. DOJ's attorney Kenneth Dintzer told Mehta Friday that the DOJ believed the court should "conclude that communicating with history off shows anti-competitive intent to hide information because they knew they were violating antitrust law."
This blog post was written based on research carried out by Jérôme Segura.
A campaign using sponsored search results is targeting home users and taking them to tech support scams.
Sponsored search results are the ones that are listed at the top of search results and are labelled “Sponsored”. They’re often ads that are taken out by brands who want to get people to click through to their website. In the case of malicious sponsored ads, scammers tend to outbid the brands in order to be listed as the first search result.
The criminals that buy the ads will go as far as displaying the official brand’s website within the ad snippet, making it hard for an unsuspecting visitor to notice a difference.
Who would, for example, be able to spot that the below ad for CNN is not legitimate. You’ll have to click on the three dots (in front of where we added malicious ad) and look at the advertiser information to see that it’s not the legitimate owner of the brand.
Only then it becomes apparent that the real advertiser is not CNN, but instead a company called Yojoy Network Technology Co., Limited.
Below, you can see another fake advertisement by the same advertiser, this time impersonating Amazon.
In our example, the scammers failed to use the correct CNN or Amazon icons, but in other cases (like another recent discovery by Jerome Segura), scammers have even used the correct icon.
The systems of the people that click one of these links are likely to assessed on what the most profitable follow-up is (using a method called fingerprinting). For systems running Windows, we found visitors are redirected to tech support scam websites such as this one.
Tech Support Scam site telling the visitor to call 1-844-476-5780
You undoubtedly know the type. Endless pop-ups, soundbites, and prompts telling the visitor that they should urgently call the displayed number to free their system of alleged malware.
These tech support scammers will impersonate legitimate software companies (i.e. Microsoft) and charge their victims hundreds or even thousands of dollars for completely bogus malware removal.
Getting help if you have been scammed
Getting scammed is one of the worst feelings to experience. In many ways, you may feel like you have been violated and angry to have let your guard down. Perhaps you are even shocked and scared, and don’t really know what to do now. The following tips will hopefully provide you with some guidance.
If you’ve already let the scammers in
Revoke any remote access the scammer has (if you are unsure, restart your computer). That should cut the remote session and kick them out of your computer.
Scan your computer for malware. The miscreants may have installed password stealers or other Trojans to capture your keystrokes. Use a program such as Malwarebytes to quickly identify and remove threats.
Change all your passwords. (Windows password, email, banking, etc.)
If you’ve already paid
Contact your financial institution/credit card company to reverse the charges and keep an eye out for future unwanted charges.
If you gave them personal information such as date of birth, Social Security Number, full address, name, and maiden name, you may want to look at some form of identity theft protection.
Write down the TeamViewer ID (9-digit code) and send it to TeamViewer’s support. They can later use the information you provide to block people/companies.
You can raise awareness by letting your friends, family, and other acquaintances know what happened to you. Although sharing your experience of falling victim to these scams may be embarrassing, educating other people will help someone caught in a similar situation and deter further scam attempts.
We don’t just report on threats – we help safeguard your entire digital identity
Cybersecurity risks should never spread beyond a headline. Protect your—and your family’s—personal information by using identity protection
Streaming services like Netflix and Peacock have already found multiple ways to aggravate paying subscribers this week.
The streaming industry has been heating up. As media giants rush to establish a successful video streaming business, they often make platform changes that test subscribers' patience and the value of streaming.
Below is a look at the most exasperating news from streaming services from this week. The scale of this article demonstrates how fast and frequently disappointing streaming news arises. Coincidentally, as we wrote this article, another price hike was announced.
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