Anthropic today released Opus 4.5, its flagship frontier model, and it brings improvements in coding performance, as well as some user experience improvements that make it more generally competitive with OpenAI’s latest frontier models.

Perhaps the most prominent change for most users is that in the consumer app experiences (web, mobile, and desktop), Claude will be less prone to abruptly hard-stopping conversations because they have run too long. The improvement to memory within a single conversation applies not just to Opus 4.5, but to any current Claude models in the apps.

Users who experienced abrupt endings (despite having room left in their session and weekly usage budgets) were hitting a hard context window (200,000 tokens). Whereas some large language model implementations simply start trimming earlier messages from the context when a conversation runs past the maximum in the window, Claude simply ended the conversation rather than allow the user to experience an increasingly incoherent conversation where the model would start forgetting things based on how old they are.

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AI systems have recently had a lot of success in one key aspect of biology: the relationship between a protein’s structure and its function. These efforts have included the ability to predict the structure of most proteins and to design proteins structured so that they perform useful functions. But all of these efforts are focused on the proteins and amino acids that build them.

But biology doesn’t generate new proteins at that level. Instead, changes have to take place in nucleic acids before eventually making their presence felt via proteins. And information at the DNA level is fairly removed from proteins, with lots of critical non-coding sequences, redundancy, and a fair degree of flexibility. It’s not necessarily obvious that learning the organization of a genome would help an AI system figure out how to make functional proteins.

But it now seems like using bacterial genomes for the training can help develop a system that can predict proteins, some of which don’t look like anything we’ve ever seen before.

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